Integrin-mediated adhesive interactions are viewed in the context of HIV transmission to susceptible cells and fertilization. The ability of a low-molecular-weight non-peptide integrin modulator to inhibit HIV infection (virus-to-cell and cell-to-cell) and sperm-egg fusion is demonstrated. It is concluded that integrin-modulating substances offer significant promise as female-controlled means for preventing sexual transmission of HIV (whatever entity acts as HIV vector in semen and other penile secretions) and as female-controlled contraceptives.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0165-0378(98)00064-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Seroprevalence of Hepatitis B and C and HIV Infections and Associated Risk Factors Among Pregnant Women Attending Antenatal Care Unit at Simada Hospital, South Gondar Zone, Northwest Ethiopia.
Biomed Res Int
January 2025
Department of Biology, College of Natural & Computational Sciences, University of Gondar, Gondar, Ethiopia.
Hepatitis and human immunodeficiency virus (HIV) are major public health issues in developing countries, including Ethiopia. These viruses can be transmitted from mother to child during birth or through contact with contaminated blood. In many areas of Ethiopia, viral hepatitis and HIV infections are significant health concerns for pregnant women.
View Article and Find Full Text PDFEffectiveness of donor notification and counseling of HIV-reactive donors in a tertiary care hospital from North India: An audit.
Asian J Transfus Sci
March 2023
Department of Pathology, UCMS and GTB Hospital, Delhi, India.
Introduction: Blood banks are responsible for notification and counseling of the reactive donors besides screening for transfusion-transmitted infections (TTIs). Donor notification and counseling is essential to protect the health of the donor by early clinical intervention and to prevent secondary transmission of infection.
Aim: The aim of this study was to determine the effectiveness of human immunodeficiency virus (HIV)-reactive donor notification and counseling in a tertiary care center.
Interpersonal relations of pregnant women post-HIV diagnosis in Thembisile Hani, South Africa.
South Afr J HIV Med
December 2024
Department of Nursing Science, School of Health Care Sciences, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
Background: HIV is a major public health issue in South Africa, with around 7.7 million people living with the virus by 2023, including 4.9 million women.
View Article and Find Full Text PDF"You're in an Image of a Man but Not a Man": A Qualitative Analysis of Intersectional Stigma Among Men with HIV Experiencing Subfertility in Rural Southwestern Uganda.
AIDS Behav
January 2025
Mbarara University of Science and Technology, Global Health Collaborative, Mbarara, Uganda.
Many men with HIV (MWH) want to have children and may encounter HIV- and infertility-related stigma experiences. Integration of reproductive health and HIV care for men is rare. When available, safer conception care focuses on HIV prevention but lacks fertility support.
View Article and Find Full Text PDFSafety, Tolerability, and Pharmacokinetics of Long-Acting Broadly Neutralizing HIV-1 Monoclonal Antibody VRC07523LS in Newborn Infants Exposed to HIV-1.
J Pediatric Infect Dis Soc
January 2025
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH Bethesda, MD, USA.
Background: Vertical HIV-1 transmission despite antiretroviral therapy may be mitigated by use of long-acting, broadly neutralizing, monoclonal antibodies (bNAb) such as VRC07523LS. The present study was designed to determine the safety and pharmacokinetics of VRC07523LS.
Methods: VRC07523LS, 80 mg/dose, was administered subcutaneously after birth to non-breastfed (Cohort 1; N=11, enrolled in USA) and breastfed (Cohort 2; N=11, enrolled in South Africa and Zimbabwe) infants exposed to HIV-1.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!