The effect of guided tissue regeneration procedures on the healing of osseous defects was studied in Sprague-Dawley rats. A full thickness flap was reflected and two 5 mm defects were made in the calvaria of 17 rats. A resorbable membrane was placed over one defect in each animal, while the remaining defect served as a control. After 3, 5, or 7 wk, healing of the osseous defects was evaluated histologically. There was no statistical difference in bone regeneration between experimental and control sites at any time period.
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