The purpose of this study was to compare the craniofacial morphology of a group of Chinese children from northern China with a group of Swedish children. Each ethnic group comprised 20 boys and 20 girls with Class I occlusion, and 20 boys and 20 girls with Class II occlusion. The ages of the children ranged from eight to ten years. Lateral cephalometric radiographs were used for the recording of a number of skeletal, dental, nasopharyngeal airway, and hyoid bone variables. The results of the comparisons of the two ethnic groups showed that the antero-posterior dimensions of the anterior cranial base and the maxilla in the Chinese children were significantly smaller than the corresponding dimensions in the Swedish children. The mean values of anterior and posterior face heights, inclination of the upper incisors, and protrusion of the lower incisors, were significantly greater in the Chinese than in the Swedish samples. In the median plane, the size of the nasopharyngeal airway was significantly greater in the Chinese than in the Swedes. This difference was due to the fact that the soft tissues covering the posterior nasopharyngeal wall were thinner in the Chinese children than in the Swedish children. In general, the ethnic differences were the same in the Class I and the Class II groups. The differences in some of the dental and skeletal characteristics found between northern Chinese and Caucasian-children are similar to previously described differences between southern Chinese and Caucasian children.
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Public Health Pract (Oxf)
June 2025
Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Nursing, 141 83, Huddinge, Sweden.
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Division Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany
Chimeric antigen receptor (CAR) T cell therapy of solid cancer remains below expectations; adding cytokine help through IL-18 has shown remarkable efficacy in first clinical trials. As IL-18 is also a powerful driver of hyperinflammatory conditions, we discuss to what extent unleashing IL-18 is a double-edged sword in CAR T cell therapies.
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Department of Learning Informatics Management and Ethics, Karolinska Institute, Stockholm, Sweden; Paediatric Emergency Department, Karolinska University Hospital, Stockholm, Sweden; Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
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Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
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J Mol Cell Cardiol Plus
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