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Background/objectives: The failure of physiological left-right (LR) patterning, a critical embryological process responsible for establishing the asymmetric positioning of internal organs, leads to a spectrum of congenital abnormalities characterized by laterality defects, collectively known as "heterotaxy". biallelic variants have recently been associated with heterotaxy syndrome and congenital heart defects (CHD). However, the genotype-phenotype correlations and the underlying pathogenic mechanisms remain poorly understood.
View Article and Find Full Text PDFIs there an association between lateral uterine localization of the placenta and pregnancy outcomes?
Arch Gynecol Obstet
January 2025
Department of Obstetrics and Gynecology, Meir Medical Center, 59 Tchernichovsky St., 44281, Kfar Saba, Israel.
Purpose: To evaluate the association between lateral placentation and adverse perinatal outcomes, including rates of small for gestational age (SGA) neonates, hypertensive (HTN) disorders, and preterm delivery, as well as postpartum hemorrhage and retained placenta.
Methods: This retrospective cohort study included all women with singleton pregnancies who underwent a trial of labor after reaching 24 weeks of gestation, at a single tertiary medical center, over a period of 6 years. The study group included women with lateral placentation.
Neglected uterine rupture… myth or reality? - A case report.
Int J Surg Case Rep
January 2025
Gynaecology-Obstetrics and Endoscopy Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V, Rabat, Morocco.
Introduction: Neglected Uterine rupture in an unscarred uterus is a rare but remains the most serious and fearsome complication in obstetrics, with high maternal and fetal risks, a neglected uterine rupture is rarer but more serious affecting the maternal prognosis with a high rate of hysterectomy.
Case Presentation: A 36-year-old patient, presented on postpartum day 4 a pelvic pain, physical examination finds patient in shock, Ultrasound showed an enlarged uterus with a discontinuity on the right lateral edge and abundant peritoneal fluid reaching Morison's pouch. The patient underwent a necessary total interadnexal hysterectomy due to the presence of a partial uterine necrosis.
Clinical factors that influence chorionic villus sampling sample size.
Arch Gynecol Obstet
January 2025
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Colorado School of Medicine, 12631 East 17th Ave, Aurora, USA.
Purpose: Our primary objective was to characterize clinical and procedural factors affecting sample size in chorionic villus sampling (CVS).
Methods: This retrospective, single-site cohort study included singleton pregnancies undergoing transabdominal (TA) and transcervical (TC) CVS between 2020 and 2023. Prenatal and maternal data were obtained from the electronic medical record.
Maternally activated connections of the ventral lateral septum reveal input from the posterior intralaminar thalamus.
Brain Struct Funct
January 2025
Department of Physiology and Neurobiology, Laboratory of Molecular and Systems Neurobiology, Eötvös Loránd University, Budapest, Hungary.
The lateral septum (LS) demonstrates activation in response to pup exposure in mothers, and its lesions eliminate maternal behaviors suggesting it is part of the maternal brain circuitry. This study shows that the density of pup-activated neurons in the ventral subdivision of the LS (LSv) is nearly equivalent to that in the medial preoptic area (MPOA), the major regulatory site of maternal behavior in rat dams. However, when somatosensory inputs including suckling were not allowed, pup-activation was markedly reduced in the LSv.
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