The role of some endogenous bioregulators in formation of cardiogenic reflectory effects on circulation were investigated in acute experiments on anesthetized animals with using various methods (direct recording of impulse activity from cardiac afferent nerves, humoral isolation of the heart). Interrelations between development of cardiogenic depressor reactions and nitric oxide production was established. Systemic inhibition of NOS led to decrease in dilatation of coronary and peripheral vessels. At the other hand dramatic suppression of cardiogenic depressor reflexes followed by inhibition of prostacyclin production. The data support the essential role of endogenous bioactive substances in formation of cardiogenic reflex effects on circulation in physiological and pathological states. We also suggest that a mayor metabolite of arachidonic acid--prostacyclin--is modulator and one of humoral components of the vagus-mediated cardiogenic depressor reflex in physiological conditions.
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[The role of endogenous bioregulators in formation of cardiogenic reflex effects on circulation].
Ross Fiziol Zh Im I M Sechenova
December 2007
The possible role of endogenous endothelium-derived bioactive substances in organization of cardiogenic depressor reflexes under cardiac receptor stimulation (by veratrine and bradykinin) was investigated in acute experiments on anesthetized rats. The results have shown that endothelium-derived bioactive substances take part in forming of the cardiogenic depressor reflex humoral components of nervous response or nervous modulators. These data contribute to understanding of the role of endogenous endothelium-derived bioactive substances (prostacyclin) and different NOS isoforms in mechanisms of depressor reflex development and species differences in their involvement in reflex vasomotor reactions.
View Article and Find Full Text PDFThis review focuses on modem data concerning the role of nitric oxide (NO) in the mechanisms of vasomotor regulation. On the background of the literature data and own experimental results, we have discussed some questions of NO integration into transmission of impulses in central and autonomic nervous system under condition of realization of cardiogenic and sinocarotid pressor and depressor reflexes, reflectory vasomotor responses formation under acute myocardial ischemia. According to literature and own functional and morphological data we suggest species differences in NO participations in mechanisms of reflex self--regulation of circulation.
View Article and Find Full Text PDF[Role of biologically active substances in the formation of cardiogenic reflex effects on circulation].
Fiziol Zh (1994)
August 2002
A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Analysis of the literary and own authors data about the participation some endogenous bioregulators (prostacyclin, bradykinin, nitric oxide) in the cardiogenic depressor reflexes formation is represented in this review. Possibility of chemosensitivity of the vagal afferent fibers for this substances and its role in the formation of cardiogenic effects on circulation is discussed.
View Article and Find Full Text PDF[The role of endothelium-dependent factors in realizing cardiogenic reflexes under normal and pathological conditions].
Fiziol Zh (1994)
September 2000
A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
We have investigated the role of NO-dependent mechanisms in the realization of cardiogenic reflexes (pressor and depressor) during the action of veratrin and serotonin on cardiac receptors, adrenergic changes of the myocardial contractile activity or the short-term period of myocardial ischemia on anaesthetized dogs cats and rats. NO take place in the development of cardiogenic depressor reflexes and decreases pressor reflexes from the cardiac receptors in dogs. Specific characteristics of these influences were asserted: the depressor reflexes decrease after systemic inhibition of NOS by L-NNA in dog but they are increased or are not altered in rats.
View Article and Find Full Text PDFThe role of some endogenous bioregulators in formation of cardiogenic reflectory effects on circulation were investigated in acute experiments on anesthetized animals with using various methods (direct recording of impulse activity from cardiac afferent nerves, humoral isolation of the heart). Interrelations between development of cardiogenic depressor reactions and nitric oxide production was established. Systemic inhibition of NOS led to decrease in dilatation of coronary and peripheral vessels.
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