Analysis of evoked activity patterns of human thalamic ventrolateral neurons during verbally ordered voluntary movements.

In the human thalamic ventralis lateralis nucleus the responses of 184 single units to verbally ordered voluntary movements and some somatosensory stimulations were studied by microelectrode recording technique during 38 stereotactic operations on parkinsonian patients. The tests were carried out on the same previously examined population of neurons classified into two groups, named A- and B-types according to the functional criteria of their intrinsic structure of spontaneous activity patterns. The evaluation of the responses of these units during functionally different phases of a voluntary movement (preparation, initiation, execution, after-effect) by means of the principal component analysis and correlation techniques confirmed the functional differences between A- and B-types of neurons and their polyvalent convergent nature. Four main conclusions emerge from the studies. (1) The differences of the patterns of A- and B-unit responses during the triggering and the execution phases of a voluntary movement indicate the functionally different role of these two cell types in the mechanisms of motor signal transmission. (2) The universal non-specific form of anticipatory A- and B-unit responses during the movement preparation and initiation of various kinds of voluntary movements reflect the integrative "triggering" processes connected with the processing and programming of some generalized parameters of a motor signal and not with the performance of a certain forthcoming motor act. (3) The expressed intensity of these "triggered" non-specific processes in the anterior parts of the ventralis lateralis nucleus indicates their relation not only to the motor but to the cognitive attentional functions forming a verbally ordered voluntary movement. (4) The appearance of the transient cross-correlations between the activities of adjacent A- and B-cells and also the synchronization of their 5 +/- 1 Hz frequency during and/or after motor test performances point to the contribution of these two populations to central mechanisms of the voluntary movement and the parkinsonian tremor. The functional role of two A- and B-cell types is discussed with references to the central mechanisms of verbally ordered voluntary movements and the parkinsonian tremor.