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Pathogen exposure misclassification can bias association signals in GWAS of infectious diseases when using population-based common control subjects.
Am J Hum Genet
February 2023
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. Electronic address:
Genome-wide association studies (GWASs) have been performed to identify host genetic factors for a range of phenotypes, including for infectious diseases. The use of population-based common control subjects from biobanks and extensive consortia is a valuable resource to increase sample sizes in the identification of associated loci with minimal additional expense. Non-differential misclassification of the outcome has been reported when the control subjects are not well characterized, which often attenuates the true effect size.
View Article and Find Full Text PDFFalse-seronegative HCV infection motivated by interference with cryoglobulins.
Adv Lab Med
May 2021
Clinical Chemistry Laboratory, Catalan Institute of Health (ICS)-Camp de Tarragona-Terres de l'Ebre, Joan XXIII University Hospital in Tarragona, Tarragona, Spain.
Objectives: Cryoglobulins (CGs) are serum proteins that undergo a reverse cold-induced precipitation . The CGs are a well-known cause of analytical interferences in several laboratory tests, leading to spurious results. With this in view, we present a case of a patient initially misdiagnosed due to CGs interference in Hepatitis C Virus (HCV) serology.
View Article and Find Full Text PDFGenotypes and Hot Spot Mutations of Hepatitis B Virus in Northwest Chinese Population and Its Correlation with Diseases Progression.
Biomed Res Int
May 2020
The State Key Laboratory of Cancer Biology, Air Force Military Medical University, Xi'an 710032, China.
Hepatitis B virus (HBV) infection is a critical incentive for chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). Different genotypes and genome mutations of HBV have been found to be related to the progression of these liver diseases. However, their clinical significance is still under debate.
View Article and Find Full Text PDFIntravenous immunoglobulin (IVIg) is a commonly utilized therapy in multiple medical subspecialities, indicated for the management of various primary and secondary immunodeficiency states and autoimmune and inflammatory conditions. A lack of awareness exists among clinicians regarding the serological downstream effects of its use. An observed phenomenon post-IVIg is the passive transfer of antibodies from the product which can lead to transiently positive hepatitis B serology in recipients.
View Article and Find Full Text PDFPediatric population health analysis of southern and central Illinois region: A cross sectional retrospective study using association rule mining and multiple logistic regression.
Comput Methods Programs Biomed
September 2019
Office of Population Science and Policy, Southern Illinois University School of Medicine, United States. Electronic address:
Background: Southern Illinois University School of Medicine (SIUSOM) collects large amounts of data every day. SIUSOM and other similar healthcare systems are always looking for better ways to use the data to understand and address population level problems. The purpose of this study is to analyze the administrative dataset for pediatric patients served by Southern Illinois University School of Medicine (SIUSOM) to uncover patterns that correlate specific demographic information to diagnoses of pediatric diseases.
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