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Correlation between serum adenosine deaminase levels and risk of diabetic foot ulcers in patients with type 2 diabetes mellitus.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
July 2024
Department of Orthopedics, Southwest Hospital, Army Medical University, Chongqing 400038, China.
Objectives: Adenosine deaminase (ADA) is a critical enzyme in the catabolism of adenosine acid during purine metabolism and plays a significant role in the diagnosis and monitoring of various diseases. This study aims to investigate the relationship between serum ADA levels and risk of diabetic foot ulcers (DFU) in patients with type 2 diabetes mellitus (T2DM), providing a clinical basis for the prevention and treatment of DFU.
Methods: A retrospective study was conducted on 2 719 T2DM patients diagnosed at the Southwest Hospital of Army Medical University from January 2019 to January 2020.
Increased levels of Matrix Metaloproteinase‐10 and Adenosine Deaminase in blood are associated with reduced cognition.
Alzheimers Dement
December 2024
University of Southampton, Southampton, UK
Background: Neuroinflammation and activation of the immune system can influence Alzheimer’s disease (AD) progression. This is mediated by inflammatory molecules, which exacerbate the production of β‐amyloid, the propagation of tau pathology, and neuronal loss. By measuring CSF markers of inflammation in a heterogeneous clinical cohort we found that levels of Adenosine Deaminase (ADA) and Matrix‐Metaloproteinase‐10 (MMP‐10) increase in patients with AD.
View Article and Find Full Text PDFA/T(N) Status Biomarkers Associate with Polymorphisms in Purinergic Signaling Genes.
Alzheimers Dement
December 2024
Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil
Background: Purinergic signaling is vital in various cellular processes like neuroinflammation, synaptic transmission, Aβ clearance, and tau phosphorylation regulation. This study aims to examine if SNPs in purinergic signaling genes are associated to A/T(N) status biomarkers in Alzheimer’s Disease through Genome Wide Association Studies.
Method: The SNPRelate package was used to analyze SNPs in genes related to purinergic signaling and A/T(N) markers.
Effects of combination mixture of with psychoactive drugs on adenosine deaminase, ectonucleosides enzymes, redox status, cognition and hemodynamic function in male rats.
Alzheimers Dement
December 2024
Federal University of Technology Akure, Ondo State, Akure, Nigeria
Background: The effect of high consumption of psychoactive substances of codeine (CDE), tramadol (TMD), and (CNB) as concoction has been associated with altered brain cognitive and neurochemical functions. However, the understanding of the complex mechanism behind the intake of co‐administration with tramadol and codeine on both cardiac and brain function, neurotransmitters, purinergic, and antioxidant enzymes activities in the brain and heart of rats remains unreported.
Method: The measure of cognition using morris water maze (MWM) and Y‐maze tests, hemodynamic parameters namely systolic blood pressure (SBP) and heart rate (HR), acetylcholinesterase (AChE), butyl‐cholinesterase (BCHE), adenosine deaminase (ADA), arginase, catalase (CAT), superoxide dismutase (SOD) enzymes’ activities, reduced glutathione (GSH) and malondialdehyde (MDA), nitric oxide (NO) levels, in the brain and heart of CNB, TMD, and CDE exposed rats was done.
Background: The progression of diabetes mellitus (DM) has been associated with changes in brain structure and function, often referred to as “diabetic encephalopathy,” which is characterized by cognitive and neurochemical dysfunction, and identifiable structural changes in brain imaging. This study investigated the effect of Moringa leaf‐supplemented diets (MLSD) on cognition, acetylcholinesterase (AChE), adenosine deaminase (ADA) and arginase activities, reactive oxygen species (ROS), total‐thiol (T‐SH), inflammatory cytokines (TNF‐α, NF‐κB, IL‐6, and IL‐10) levels, caspase‐3 expression, and nuclear factor erythroid 2–related factor‐2 (Nrf2) levels in the brain of DM rats treated with 25 mg/kg bwt acarbose (ACA).
Method: The normal control (NC) rats and diabetic rats were grouped as follows: NC rats, untreated DM rats, DM rats plus ACA, DM rats plus ACA and 2% MLSD, and DM rats plus ACA and 4% MLSD.
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