In establishing the best practice and/or evaluating any new process or procedures it is essential that apart from the compliance to specification, provided by the Guidelines (i.e. AABB or UK-BTS/ NIBSC), the changes that might occur in the activation states, and other regulatory mechanisms should be considered. Of particular relevance are the changes in the levels of FVIII in relation to its carrier protein and stabiliser von Willebrand factor; the levels of contact activation and serine proteases and the level of cellular fragmentation/microvesiculation due to shear induced stress in the cellular contents of blood and the development of cytokines. This brief original report compares the above parameters for three types of FFP, cryoprecipitate and the cryosupernatant in respect to same new in house quality monitoring criteria of acceptability.
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Comparing cryoprecipitate-poor plasma to fresh frozen plasma as replacement therapy in thrombotic thrombocytopenic purpura: An updated meta-analysis.
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Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile. Electronic address:
Background: Cryoprecipitate-poor plasma (CPP) has been suggested as a promising alternative to the standard fresh frozen plasma (FFP) in plasma exchange therapy (TPE) for thrombotic thrombocytopenic purpura (TTP) given its lower concentrations of von Willebrand Factor (VWF). However, its efficacy and safety remain a topic of debate.
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The History of Rare Bleeding Disorders.
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Transfusion Research Unit, Monash University, Public Health and Preventive Medicine, Melbourne, Australia; Department of Haematology, Monash Health, Melbourne, Australia; Department of Haematology, Alfred Health, Melbourne, Australia.
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School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Qld 4000, Australia.
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