After some patients were exposed to a blood product from a donor with Creutzfeld-Jakob disease, Winnipeg hospitals had to decide whether to inform them of the possibly minuscule health risk. The Salvation Army Grace Hospital decided to inform its patients, citing their fundamental right to facts regarding their own health; their need to make a responsible, informed decision regarding donation of their own blood or organs; and the need to maintain the trust and confidence of the public in the wake of the Krever inquiry.
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Z Gastroenterol
January 2025
Klinik für Allgemeine Innere Medizin, Onkologie/Hämatologie, Gastroenterologie und Infektiologie, Klinikum Esslingen, Esslingen, Germany.
Prion diseases pose a challenge for flexible reusable endoscopes. Especially for the new variant of Creutzfeld Jakob disease (vCJD) there is currently no suitable processing procedure. In these patients only disposable endoscopes are hygienically safe.
View Article and Find Full Text PDFCureus
August 2024
Neurology, Advocate Lutheran General Hospital, Park Ridge, USA.
Creutzfeldt-Jakob disease (CJD) is a rare, rapidly progressive, fatal neurodegenerative disorder caused by an accumulation of protein-containing particles called prions in the central nervous system. The Heidenhain variant (HvCJD) is a rare subtype of CJD that presents with predominantly visual symptoms at onset. The patient presented in this case had several weeks of visual symptoms prior to hospital admission.
View Article and Find Full Text PDFCureus
July 2024
Neurology, University Hospital Sussex National Health Services (NHS) Foundation Trust, Chichester, GBR.
Sporadic Creutzfeldt-Jakob disease (SCJD) is a rare neurodegenerative disease with a very low prevalence. The aetiology is theorised to be genetic. Modern laboratory techniques, such as the real-time quaking-induced conversion (RT-QuIC) assay, have allowed us to diagnose CJD with greater sensitivity and specificity.
View Article and Find Full Text PDFMethods Enzymol
May 2024
Institute of Molecular Physical Science, ETH Zürich, Zürich, Switzerland. Electronic address:
Amyloid aggregates with unique periodic structures have garnered significant attention due to their association with numerous diseases, including systemic amyloidoses and the neurodegenerative diseases Parkinson's, Alzheimer's, and Creutzfeld-Jakob. However, more recent investigations have expanded our understanding of amyloids, revealing their diverse functional biological roles. Amyloids have also been proposed to have played a significant role in prebiotic molecular evolution because of their exceptional stability, spontaneous formation in a prebiotic environment, catalytic and templating abilities, and cooperative interaction with fatty acids, polysaccharides, and nucleic acids.
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