Physician executives, especially those who are new to the profession or who are beginning career moves to positions of increasingly higher management responsibilities, are faced with the decision of maintaining a level of clinical practice or leaving practice altogether. This article explores the advantages and the disadvantages of mixing practice and management that have been expressed by physician executives.
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Identification of key gene signatures for predicting chemo-immunotherapy efficacy in extensive-stage small-cell lung cancer using machine learning.
Lung Cancer
January 2025
Internal Medicine III, Wakayama Medical University, Wakayama, Japan.
Objectives: The lack of definitive biomarkers presents a significant challenge for chemo-immunotherapy in extensive-stage small-cell lung cancer (ES-SCLC). We aimed to identify key genes associated with chemo-immunotherapy efficacy in ES-SCLC through comprehensive gene expression analysis using machine learning (ML).
Methods: A prospective multicenter cohort of patients with ES-SCLC who received first-line chemo-immunotherapy was analyzed.
Visual analysis of the research frontiers, hotspots and development trends of immunization programs for women and children.
Hum Vaccin Immunother
December 2025
Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xian, Shanxi, PR China.
The objective of this study is to gain insight into the current research frontiers, hotspots, and development trends in the field of immunization programs for women and children, and to provide scientific guidance and reference for follow-up research. Based on all the original research papers related to the research on immunization programs for women and children in the Web of Science Core Collection (WoSCC) database, bibliometric studies and visual analysis were carried out to explore the research frontiers, hotspots and development trends, and to analyze the risk factors affecting the vaccination coverage of immunization programs for women and children. Eight hundred forty-three papers obtained from 1,552 institutions in 96 countries/regions from January 1950 to August 2024, coauthored by 4,343 authors.
View Article and Find Full Text PDFContribution of Open Access Databases to Intensive Care Medicine Research: Scoping Review.
J Med Internet Res
January 2025
Department of Anesthesiology and Critical Care, CHU Rouen, Rouen, France.
Background: Intensive care units (ICUs) handle the most critical patients with a high risk of mortality. Due to those conditions, close monitoring is necessary and therefore, a large volume of data is collected. Collaborative ventures have enabled the emergence of large open access databases, leading to numerous publications in the field.
View Article and Find Full Text PDFUsability of a Cloud-Based Home Healthcare Client Monitoring Platform: A Simulation-Based Approach.
Rehabil Nurs
December 2024
Elaine Marieb College of Nursing, University of Massachusetts Amherst, Amherst, MA, USA.
Purpose: The aim of this study was to assess the usability of a cloud-based home healthcare monitoring platform (CHHM).
Design: A proof of concept using a simulated client scenario was used in this study.
Methods: Using a mixed-methods approach, a convenience sample of 14 nursing students was used to assess the usability of CHHM during a simulation.
Background: The Wound Care Collaborative Community (WCCC) assesses shortcomings and unmet needs in wound care by partnering with key stakeholders, such as the National Institutes of Health, the US Food and Drug Administration (FDA), industry leaders, and expert health care providers and researchers, to advance the study of wound healing. Through this work, the WCCC has identified a few key barriers to innovation in wound care. The WCCC aims to accelerate the development of science-based, patient-centered solutions and address public policy challenges related to ensuring patients receive early access to innovative treatment options.
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