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Surgical intervention in traumatic brain injury: a systematic review and meta-analysis of decompressive craniotomy.
Eur J Trauma Emerg Surg
January 2025
Division of Neurosurgery, Department of Surgery, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Background: Traumatic brain injury (TBI) is considered a major cause of death globally, resulting from trauma. Decompressive craniectomy (DC) may improve functional outcomes in patients with TBI and its associated complications. This study was designed to determine safety and efficacy of DC in improving clinical outcomes in TBI patients compared to standard therapy.
View Article and Find Full Text PDFFluid Management Bundle in Critically Ill Children With Respiratory Failure Is Associated With a Reduced Prevalence of Excess Fluid Accumulation.
Pediatr Crit Care Med
January 2025
Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.
Objectives: To report the feasibility of a fluid management practice bundle and describe the pre- vs. post-implementation prevalence and odds of cumulative fluid balance greater than 10% in critically ill pediatric patients with respiratory failure.
Design: Retrospective cohort from May 2022 to December 2022.
Longer disease progression milestone-free time in people with amyotrophic lateral sclerosis treated versus not treated with intravenous edaravone: results from an administrative claims analysis.
J Comp Eff Res
January 2025
Mitsubishi Tanabe Pharma America, Inc., Health Economics and Outcomes Research (HEOR), Medical Affairs, Jersey City, NJ, 07310 USA.
To estimate time-to-progression milestones in people with amyotrophic lateral sclerosis (PALS) treated versus not treated with intravenous (IV) edaravone (Radicava IV, Mitsubishi Tanabe Pharma America [MTPA], hereafter "IV edaravone") in a real-world setting. IV edaravone is US FDA approved for the treatment of ALS and was shown in clinical trials to slow the rate of physical functional decline. This retrospective observational analysis included PALS continuously enrolled in Optum's Clinformatics Data Mart between 8 August 2017 and 31 December 2021.
View Article and Find Full Text PDFStudy on a compact pulse forming line-Marx type high voltage pulse generator.
Rev Sci Instrum
January 2025
College of Advanced Interdisciplinary Studies, National University of Defense Technology, Changsha 410072, China.
High power pulse generators are moving in the direction of compact, solid-state, and stable working in a relatively long time. In this paper, a compact pulse forming line-Marx type high power pulse generator, based on a ceramic pulse forming line and a spark gap switch with carbide modified graphite electrodes, is studied numerically and experimentally. Specifically, a ceramic based pulse forming line with high relative permittivity was used to achieve long pulse duration in a limited dimension.
View Article and Find Full Text PDFPost-exercise neural plasticity is augmented by adding blood flow restriction during low work rate arm cycling.
Exp Physiol
January 2025
Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Perth, Australia.
Blood flow restriction (BFR) combined with low work rate exercise can enhance muscular and cardiovascular fitness. However, whether neural mechanisms mediate these enhancements remains unknown. This study examined changes in corticospinal excitability and motor cortical inhibition following arm cycle ergometry with and without BFR.
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