Objective: To establish and quantify the point during inspiration that the Autohaler (AH) inhalation system releases a metered dose of aerosol (placebo). The second objective was to determine if the Autohaler system actuates consistently, regardless of the canister life.
Design: Double-blind, randomized, two-period crossover, one-day trial.
Setting: Community based allergy and asthma clinic.
Participants: Twelve patients with mild to moderate asthma.
Results: Mean verbal training time for the AH which included the patient demonstrating their ability to correctly use the AH was approximately 6 minutes. The mean time for actuation for the AH early in its canister life ("new canister") was 195 msec compared to 205 msec for the AH late in its canister life ("old canister") (p = 0.589). This represented the early part of inspiration as patients had a mean inspiratory duration of 2231 msec for the "new" AH and 2343 msec for the "old" AH. The mean percentage of inspiration time required to actuate the "new" AH was 8.92% compared to 8.82% for the "old" AH. Patients rated the system as easier to much easier to use compared with their current standard press and breathe inhaler.
Conclusions: The AH consistently actuates early during inspiration, which is considered the optimal time for drug delivery, regardless of the canister life.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1089/jam.1995.8.187 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Carbon Footprint of Fluorinated Gases Used in Endothelial Keratoplasty.
Cornea
October 2024
Newcastle Eye Centre, Royal Victoria Infirmary, Newcastle Upon Tyne, United Kingdom.
Purpose: The purpose of this study was to examine the direct impact on carbon emissions attributed to the use of fluorinated gases in endothelial keratoplasty (EK) procedures using gas tamponade and to evaluate the respective carbon footprint of different gas delivery systems used in EK procedures.
Methods: In this retrospective, single-center environmental impact study, all corneal procedures using fluorinated gases between January 2021 and January 2024 at the Royal Liverpool University Hospital were reviewed and included. The CO2 equivalent emissions were calculated based on the mass of each fluorinated gas used, following the guidelines of the Intergovernmental Panel on Climate Change.
Effort in manual operation of reproductive health cryostorage facilities.
Reprod Biomed Online
November 2024
TMRW Life Sciences, Inc., New York, NY, USA. Electronic address:
Research Question: What areas of manual IVF cryostorage operations are common to the safe operation of IVF cryostorage facilities and require effort from embryologists?
Design: Observational time and motion data were collected by two observers equipped with the digital cameras over 2 weeks at four well-characterized US IVF centres (sites α, β, γ and δ) from 12 participants performing cryostorage tasks. To understand the work processes of the different sites and assist in the data analysis, informal interviews were conducted with the study participants and laboratory directors. Data were analysed to identify work processes that might be eliminated or diminished by automation and software improvements.
Modeling moisture change of packaged dry tablet dosage forms under consumer use condition.
Drug Dev Ind Pharm
July 2024
Department of Pharmaceutical Engineering, Kyungnam University, Changwon, South Korea.
A simple mathematical model based on product's moisture sorption isotherm and package's moisture transmission was developed to predict moisture content of dry solid tablets during consumers' use, which is useful for determination of in-use shelf life (ISL) or secondary shelf life. The moisture increase depending on amount of product remaining in the package was accounted for in the mass balance equation on the package. The model was first verified by literature data of desiccant canisters in a plastic bottle of high density polyethylene exposed to two environmental conditions (25 °C and 60% relative humidity (RH); 40 °C and 75% RH) simulating in-use of removing one canister each day.
View Article and Find Full Text PDFWound Fluid Extracellular Microvesicles: A Potential Innovative Biomarker for Wound Healing.
Plast Reconstr Surg Glob Open
May 2024
Department of Surgery, College of Medicine and Life Science, University of Toledo, Toledo, Ohio.
Background: Extracellular vesicles, or microvesicles, are a large family of membrane-bound fluid-filled sacs that cells release into the extracellular environment. Extracellular microvesicles (EMVs) are essential for cell-to-cell communications that promote wound healing. We hypothesize a correlation between the concentration of EMVs in wound fluid and the percentage of wound healing in treated chronic, nonhealing, wounds.
View Article and Find Full Text PDFDevelopment of a self-microemulsifying drug delivery system to deliver delamanid via a pressurized metered dose inhaler for treatment of multi-drug resistant pulmonary tuberculosis.
Int J Pharm
April 2024
Drug Delivery System Excellence Center, Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand. Electronic address:
Tuberculosis (TB) is a serious health issue that contributes to millions of deaths throughout the world and increases the threat of serious pulmonary infections in patients with respiratory illness. Delamanid is a novel drug approved in 2014 to deal with multi-drug resistant TB (MDR-TB). Despite its high efficiency in TB treatment, delamanid poses delivery challenges due to poor water solubility leading to inadequate absorption upon oral administration.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!