The authors report two cases of occupation-related anthrax meningitis; one was direct contamination from a diseased animal; the second was due to handling of bone powder imported from India. The pathological pattern of involvement of the meninges and brain is described and discussed.
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In endemic areas with a compatible epidemiological context, clinicians should consider anthrax as a potential diagnosis. The disease can present with diverse clinical manifestations, including cutaneous, gastrointestinal, respiratory, or central nervous system infections.
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Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.
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Efficient treatment of anthrax-related meningitis in patients poses a significant therapeutic challenge. Previously, we demonstrated in our anthrax meningitis rabbit model that ciprofloxacin treatment is ineffective with most of the treated animals succumbing to the infection. Herein we tested the efficacy of doxycycline in our rabbit model and found it highly effective.
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