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The 'escape from flatland' concept has gained significant traction in modern drug discovery, emphasizing the importance of three-dimensional molecular architectures, which serve as saturated bioisosteres of benzenoids. Bicyclo[1.1.

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Hybridized triboelectric nanogenerators for simultaneously scavenging droplet and wind energies.

Front Chem

January 2025

Information Science Academy, China Electronics Technology Group Corporation, Beijing, China.

Triboelectric nanogenerators (TENGs) have attracted great attention due to the simple manufacturing process, low cost, and diverse forms of energy harvesting. However, the energy collected by individual TENG is relatively limited, making it necessary to develop new method to enhance the energy harvesting capability of TENG. Here, we design a hybridized TENG that integrates a droplet-driven TENG and a wind-driven TENG, which exhibits excellent electrical performance.

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A low-cost method of green hydrogen production via the modification of a lead acid battery has been achieved, resulting in a hydrogen flow rate of 5.3 L min from a 20-cell string. The electrochemical behavior and catalytic effect of various metal additives on the hydrogen evolution reaction (HER) was evaluated using cyclic voltammetry.

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Baseline tumour vessel perfusion as a non-invasive predictive biomarker for immune checkpoint therapy in non-small-cell lung cancer.

BMJ Oncol

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Cyrus Tang Medical Institute, State Key Laboratory of Radiation Medicine and Prevention, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, Jiangsu, China.

Objective: Current biomarkers for predicting immunotherapy response in non-small-cell lung cancer (NSCLC) are derived from invasive procedures with limited predictive accuracy. Thus, identifying a non-invasive predictive biomarker would improve patient stratification and precision immunotherapy.

Methods And Analysis: In this retrospective multicohort study, the discovery cohort included 205 NSCLC patients screened from ORIENT-11 and an external validation (EV) cohort included 99 real-world NSCLC patients.

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