Bioabsorbable polymer/inorganic phosphate fiber composites are prone to rapid degradation due to water sensitivity of the interface between the degradable polymer and the degradable fiber. This article describes successful fabrication and laboratory evaluation of a candidate bioabsorbable composite implant material with mechanical properties similar to bone. The composite studied was poly(ortho ester) reinforced with randomly-oriented, crystalline microfibers of calcium-sodium-metaphosphate. The component materials showed no acute cytotoxicity as determined by tissue culture agar overlay. Treating the microfibers with a diamine-silane coupling agent improved mechanical properties and slowed degradation in saline, but strength still decreased 50% in 1 week. When the composite material was then coated with a layer of matrix polymer alone it retained 70% of its strength and 70% of its stiffness after 4 weeks exposure to 7.4 pH Tris-buffered saline at body temperature. The marked improvement with the coating can be attributed to the hydrophobicity of poly(ortho esters).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jab.770030306 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Low-Impedance Hybrid Carbon Structures on SiO: A Sequential Gas-Phase Coating Approach.
Small Methods
January 2025
BCMaterials, Basque Centre for Materials, Applications and Nanostructures; UPV/EHU Science Park, Leioa, 48940, Spain.
Carbon coating on SiO surface is crucial for enhancing initial Coulombic efficiency (ICE) and cycling performance in batteries, while also buffering volume expansion. Despite its market prevalence, the effects of the carbon layer's quality and structure on the electrochemical properties of SiO remain underexplored. This study compares carbon layers produced via gas-phase and solid-phase coating methods, introducing an innovative technique that sequentially uses two gases to develop a low-impedance hybrid carbon structure.
View Article and Find Full Text PDFDeep Eutectic Solvents Meet Non-Aqueous Cosolvents: A Modeling and Simulation Perspective-A Tutorial Review.
J Chem Eng Data
January 2025
Department of Chemical and Geological Sciences, University of Cagliari, 09042 Monserrato, Italy.
Deep eutectic solvents (DESs) have recently gained attention due to their tailorable properties and versatile applications in several fields, including green chemistry, pharmaceuticals, and energy storage. Their tunable properties can be enhanced by mixing DESs with cosolvents such as ethanol, acetonitrile, and water. DESs are structurally complex, and molecular modeling techniques, including quantum mechanical calculations and molecular dynamics simulations, play a crucial role in understanding their intricate behavior when mixed with cosolvents.
View Article and Find Full Text PDFFracture characteristics of human cortical bone influenced by the duration of glycation.
JBMR Plus
February 2025
Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 22529 Hamburg, Germany.
Advanced glycation end products (AGEs) accumulate in various tissues, including bone, due to aging and conditions like diabetes mellitus. To investigate the effects of AGEs on bone material quality and biomechanical properties, an study utilizing human tibial cortex, sectioned into 90 beams, and randomly assigned to three mechanical test groups was performed. Each test group included ribose ( = 0.
View Article and Find Full Text PDFElemental Germanium Activation and Catalysis Enabled by Mechanical Force.
Angew Chem Int Ed Engl
January 2025
Sichuan University West China Hospital, State key laboratory of biotherapy, Renming South Road 17, 610041, Chengdu, CHINA.
In the realm of materials science and chemical industry, germanium emerges as a strategic resource with distinctive properties that extend its applicability beyond traditional electronics and optics into the promising field of chemical catalysis. Despite its significant role in advanced technological applications, the potential of elemental germanium as a catalyst remains unexplored. Leveraging recent developments in mechanochemistry, this study introduces a groundbreaking approach to activate elemental germanium via mechanical force, facilitating the Reformatsky reaction without the reliance on external reducing agents.
View Article and Find Full Text PDFThe Unusual Mesophases and Properties Exhibited by a Family of Glycosteroids.
Chemistry
January 2025
Universite Claude Bernard Lyon 1, ICBMS, Bâtiment Lederer, 1 Rue Victor Grignard, F-69622, Villeurbanne, FRANCE.
In this article we describe research on the synthesis and characterization of a family of "Janus" amphiphiles composed of disaccharide head groups and alkaloid units joined together via a methylene linker, and bearing a lateral aliphatic chain of varying length. The condensed phases formed by self-organization of the products as a function of temperature were characterized by differential scanning calorimetry, thermal polarized light microscopy, and small angle X-ray scattering, allied with computational modelling and simulations. Structural studies on heating specimens from the solid showed that some homologues exhibited lamellar, columnar and bicontinuous mesophases, whereas the same homologues revealed different phase sequences on cooling from the amorphous liquid.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!