Technology in the field of wound management is constantly progressing as researchers search for the ideal wound dressing. The regulatory situation for wound-care products can be confusing because in some cases they are considered to be pharmaceuticals and in others they are deemed to be medical devices. In addition, the situation has not been assisted by the system of risk classification in the Medical Device Directive. This article highlights the issues and provides an update on the latest position.
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Wounds from gunshots and other explosive devices are a source of loss of substances directly or secondary to a well- conducted debridement. In addition, these types of wounds are by definition contaminated. The major challenge in this context for any surgeon remains coverage.
View Article and Find Full Text PDFA multifunctional photothermal electrospun PLGA/MoS@Pd nanofiber membrane for diabetic wound healing.
Regen Biomater
December 2024
Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration, Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed By the Province and Ministry, Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Injury caused by excess reactive oxygen species (ROS) may lead to susceptibility to bacterial infection and sustained inflammatory response, which are the major factors impeding diabetic wound healing. By utilizing optimal anti-inflammatory, antioxidant and antibacterial biomaterials for multifunctional wound dressings is critical in clinical applications. In this study, a novel electrospun PLGA/MoS@Pd nanofiber membrane was synthesized by encapsulating antioxidant and near-infrared (NIR) responsive MOS@Pd nanozymes in PLGA nanofibers to form a multifunctional dressing for diabetic wound repair.
View Article and Find Full Text PDFSurgical site infection following incisional negative pressure wound therapy in lower limb amputation closure: A randomized controlled trial.
J Educ Health Promot
December 2024
Department of General Surgery, All India Institute of Medical Sciences Jodhpur, Rajasthan, India.
Background: Major amputations are a standard procedure being done for various etiologies of the lower limb. Surgical site infections often complicate the postoperative outcome of patients. Negative pressure wound therapy has evolved to have a preventive role in SSI.
View Article and Find Full Text PDFRegeneration of the skin wound by two different crosslinkers: and studies.
Iran J Basic Med Sci
January 2025
Tissue Engineering and stem cells research center, Shahroud University of Medical Sciences, Shahroud, Iran.
Objectives: For designing a suitable hydrogel, two crosslinked Alginate/ Carboxymethyl cellulose (Alg/CMC) hydrogel, using calcium chloride (Ca) and glutaraldehyde (GA) as crosslinking agents were synthesized and compared.
Materials And Methods: All samples were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Blood compatibility (BC), Blood clotting index (BCI), weight loss (WL), water absorption (WA), pH, and Electrochemical Impedance Spectroscopy (EIS). Cell viability and cell migration were investigated using the MTT assay and the wound scratch test, respectively.
[Effectiveness of modified single patellar tunnel medial patella femoral ligament reconstruction for recurrent patellar dislocation].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
January 2025
Department of Sports Medicine, the First Affiliated Hospital of Kunming Medical University, Kunming Yunnan, 650032, P. R. China.
Objective: To investigate the effectiveness of modified single patellar tunnel medial patella femoral ligament (MPFL) reconstruction in the treatment of recurrent patellar dislocation.
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