Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Prognostic value of immune biomarkers in melanoma loco-regional metastases.
PLoS One
January 2025
Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway.
The prognosis for patients with melanoma loco-regional metastases is very heterogenous. Adjuvant PD-L1-inhibitors have improved clinical outcome for this patient group, but the prognostic impact of tumour PD-L1 expression and number of tumour infiltrating lymphocytes (TILs) is still largely unknown. Here, we investigated the impact on survival for CD3, CD8, FOXP3 and PD-L1 TIL counts and tumour PD-L1 expression in melanoma loco-regional metastases.
View Article and Find Full Text PDFSignals of propaganda-Detecting and estimating political influences in information spread in social networks.
PLoS One
January 2025
Department of Information Technologies, Faculty of Economics and Management, Czech University of Life Sciences Prague, Prague, Czech Republic.
Social networks are a battlefield for political propaganda. Protected by the anonymity of the internet, political actors use computational propaganda to influence the masses. Their methods include the use of synchronized or individual bots, multiple accounts operated by one social media management tool, or different manipulations of search engines and social network algorithms, all aiming to promote their ideology.
View Article and Find Full Text PDFFood hardness preference reveals multisensory contributions of fly larval gustatory organs in behaviour and physiology.
PLoS Biol
January 2025
Department of Biology, University of Fribourg, Fribourg, Switzerland.
Article Synopsis
- Food is a multisensory experience, relying on visuals, taste, smell, and, surprisingly, texture to assess nutritional value and safety.
- Despite being overlooked, texture offers crucial information about food's physical properties, like hardness and liquidity.
- Recent findings show that some sensory neurons are not limited to specific stimuli; instead, they can respond broadly, indicating greater sensory complexity than previously thought.
Antiproliferative activity of a series of copper(II) complexes derived from a furan-containing -acylhydrazone: monomers, dimers, charge status, and cell mechanistic studies on triple negative breast cancer cells.
Dalton Trans
January 2025
CEQUINOR (UNLP, CCT-CONICET La Plata, asociado a CIC), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Blvd. 120 No. 1465, La Plata (1900), Argentina.
In this work, we evaluated the anticancer activity of compounds 1 (mononuclear) and 2 (dinuclear) copper(II) coordination compounds derived from the ligand 5-methylsalicylaldehyde 2-furoyl hydrazone (H2L) over MDA-MB-231 Triple-negative breast cancer (TNBC) cells, and compared their activities with that of a newly synthesized, protonated, dinuclear analogue of 2 (complex 3). Here, we report the synthesis of compound 3 and it has been characterized in the solid state (X-ray diffraction, FTIR) and in solution (EPR, UV-Vis, ESI) as well as its electrochemical profile. Complexes 1-3 impaired cell viability from 0.
View Article and Find Full Text PDFEffect of laparoscopic cholecystectomy on plasma levels of EETs, arachidonic acids derived lipid mediators.
Postgrad Med J
January 2025
Department of Medical Biochemistry, Faculty of Medicine, Niğde Omer Halisdemir University, Niğde, 51000, Turkey.
Background: Epoxyeicosatrienoic acids (EETs) are closely associated with lipoprotein metabolism, and changes in lipid profiles potentially affect their levels and functions. Given the alterations in lipid metabolism after cholecystectomy, this study aimed to investigate the levels of four EET regioisomers (free and esterified) and lipid profiles in patients with cholelithiasis after laparoscopic cholecystectomy (LC) and explore correlations between these parameters.
Methods: This prospective study involved 40 patients with symptomatic cholelithiasis who underwent LC.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!