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Building Localized NADP(H) Recycling Circuits to Advance Enzyme Cascadetronics.
Angew Chem Int Ed Engl
January 2025
University of Oxford, Chemistry, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
The catalytic action of enzymes of a cascade trapped within a mesoporous electrode material is simultaneously energized, controlled and observed through the efficient, reversible electrochemical NAD(P)(H) recycling catalyzed by one of the enzymes. In their nanoconfined state, nicotinamide cofactors are tightly channeled current carriers, mediating multi-step reactions in either direction (oxidation or reduction) with a rapid response time. By incorporating a hydrogen‑borrowing enzyme pair, the internal action of which opposes the external voltage bias driving oxidation or reduction, a reduction process can be performed under overall oxidizing conditions, and vice versa.
View Article and Find Full Text PDFRe-locative guided search optimized self-sparse attention enabled deep learning decoder for quantum error correction.
Sci Rep
January 2025
Department of Mathematics, School of Advanced Sciences, VIT-AP University, Besides AP Secretariate, Amaravati, Andhra Pradesh, 522237, India.
Heavy hexagonal coding is a type of quantum error-correcting coding in which the edges and vertices of a low-degree graph are assigned auxiliary and physical qubits. While many topological code decoders have been presented, it is still difficult to construct the optimal decoder due to leakage errors and qubit collision. Therefore, this research proposes a Re-locative Guided Search optimized self-sparse attention-enabled convolutional Neural Network with Long Short-Term Memory (RlGS2-DCNTM) for performing effective error correction in quantum codes.
View Article and Find Full Text PDFWas extinction of New Zealand's avian megafauna an unavoidable consequence of human arrival?
Sci Total Environ
January 2025
School of Biological Sciences, University of Adelaide, Adelaide, SA 5000, Australia; The Environment Institute, University of Adelaide, Adelaide, SA 5000, Australia; Center for Macroecology, Evolution, and Climate, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark; Center for Global Mountain Biodiversity, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark. Electronic address:
Human overexploitation contributed strongly to the loss of hundreds of bird species across Oceania, including nine giant, flightless birds called moa. The inevitability of anthropogenic moa extinctions in New Zealand has been fiercely debated. However, we can now rigorously evaluate their extinction drivers using spatially explicit demographic models capturing species-specific interactions between moa, natural climates and landscapes, and human colonists.
View Article and Find Full Text PDFDevelopment of a nasal spray based on cyclodextrin/hydrophobically-modified hydroxypropyl-methyl cellulose for the prevention of viral respiratory infections.
Int J Biol Macromol
January 2025
Department of Drug Sciences, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy. Electronic address:
The work aims to develop mucoadhesive and thermo-responsive in situ gelling systems, using hydrophobically-modified hydroxypropyl-methyl cellulose (Sangelose, SG) and beta-cyclodextrin (β-CD) derivatives, for preventing viral respiratory infections. Eight SG/CD systems with varying CD concentrations were evaluated for rheological properties, mucoadhesiveness, spreadability and sprayability via nasal devices; cytotoxicity was in vitro investigated on reconstituted nasal epithelia. Additionally, droplet size distribution and spray deposition were assessed for the most promising systems.
View Article and Find Full Text PDFUnveiling Heavier Dihydropyridine Chalcogenol Esters in Metallaphotoredox Catalyst-Enabled Regioselective Hydrothio(seleno)carbonylation.
Org Lett
January 2025
School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Thiruvananthapuram 695551, Kerala, India.
Herein, aromaticity-driven thio(seleno)ester group transfer from novel 1,4-dihydropyridine thio(seleno)esters to alkene feedstocks is disclosed by merging palladium and photoredox catalysis. In this process, photoactivation of dihydropyridine thio(seleno)esters is integrated with regioselective hydrometalation of alkenes, avoiding photoinduced Pd-C bond homolysis of organopalladium intermediates. Additionally, a regioselective hydroselenocarbonylation of an alkene is accomplished for the first time using a bench-stable selenoester reagent.
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