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The topic of the timing of the manifestation of age-associated diseases (as an indirect indicator of accelerated population aging) after the transfer of COVID-19 remains an urgent area in scientific research. Early targeted diagnosis can significantly reduce the consequences of pathology, in connection with which the features of the manifestation of various nosologies in the post-COVID period were studied. The materials were the accounting and statistical data of the municipal polyclinics of the Sakhalin Region for the pre-COVID (2017-2019) and post-COVID (2022-2023) periods.

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From the age of 25-30, the likelihood of developing pathological processes associated with aging begins to increase. Age-associated diseases (AAD) are a heterogeneous group of pathologies that are more likely to develop as they age. Clinically, the early development of AAD is identical to premature aging with all the ensuing consequences.

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Molecular profiling of pediatric and young adult colorectal cancer reveals a distinct genomic landscapes and potential therapeutic avenues.

Sci Rep

June 2024

Unit of Hereditary Digestive Tract Tumors, Fondazione IRCCS Istituto Nazionale Dei Tumori Di Milano, Milano, Italy.

Colorectal cancer (CRC) is a global health concern, and the incidence of early onset (EO) CRC, has an upward trend. This study delves into the genomic landscape of EO-CRC, specifically focusing on pediatric (PED) and young adult (YA) patients, comparing them with adult (AD) CRC. In this retrospective monocentric investigation, we performed targeted next-generation sequencing to compare the mutational profile of 38 EO-CRCs patients (eight PED and 30 YA) to those of a 'control group' consisting of 56 AD-CRCs.

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Acute abdomen in pediatric radiology.

Rofo

May 2024

Department of Pediatric Radiology Olgahospital, Klinikum Stuttgart Olgahospital Frauenklinik, Stuttgart, Germany.

Article Synopsis
  • * The review categorizes acute abdomen causes into three age groups: newborns, infants/toddlers, and school-age children, highlighting different congenital and acquired conditions relevant to each group.
  • * Sonography and conventional X-ray are preferred imaging methods for younger children due to lower radiation exposure and ease of use, while MRI is used for specific cases, emphasizing the need for close collaboration between clinicians and radiologists.
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[Frailty in the Emergency Department].

Dtsch Med Wochenschr

November 2023

Schwerpunkt Geriatrie, Klinik für Innere Medizin 2, Klinikum Nürnberg, Paracelsus Medizinische Privatuniversität Nürnberg, Nürnberg.

Frailty affects approximately one in two patients over 70 years of age in the emergency department. These are inadequately identified as high-risk patients using conventional triage tools. Frailty screening improves the identification of high-risk patients with increased hospitalisation and readmission rates, 30-day and one-year mortality.

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