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The impact of X-rays on cardiac hydrometabolism and the regulatory role of AS-IV.
Int Immunopharmacol
December 2024
Gansu University of Chinese Medicine, LanZhou, China; Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and the Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities, Gansu University of Chinese Medicine, Lanzhou, China; Key Laboratory of Dunhuang Medicine and Transformation at Provincial and Ministerial Level, Lanzhou, China. Electronic address:
Background: Radiation-induced cardiac injury has emerged as a significant pathological entity, with many studies focusing on the fibrotic changes in myocardial tissue. However, these do not offer solutions for the clinical prevention and treatment of radiation-induced heart disease. Regulating hydrometabolism presents a potential therapeutic target for the management of cardiovascular diseases.
View Article and Find Full Text PDFNovel Molecular Mechanisms Underlying the Ameliorative Effect of Platelet-Rich Plasma against Electron Radiation-Induced Premature Ovarian Failure.
Int J Mol Sci
September 2024
Department of Digital Oncomorphology, National Medical Research Centre of Radiology, 2nd Botkinsky Pass., 3, 125284 Moscow, Russia.
Article Synopsis
- Radiotherapy can lead to premature ovarian failure and infertility in cancer patients, highlighting the need for ovarian radioprotection methods.
- Electron irradiation is a promising but under-researched option that has less toxic effects on surrounding tissues compared to other radiation types.
- The study shows that leukocyte-poor platelet-rich plasma can mitigate the negative effects of electron irradiation on ovarian function by promoting healing and reducing inflammation through specific cellular mechanisms.
Pelvic Radiation Therapy Increases Risk of Pouch Failure in Patients with Inflammatory Bowel Disease and Ileal Pouch.
Dig Dis Sci
September 2024
Division of Gastroenterology and Hepatology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL, 32224, USA.
Background: The effect of radiation on the ileal pouch is less well studied in patients with inflammatory bowel disease (IBD) and ileal pouch-anal anastomosis.
Aims: This retrospective study investigates the impact of external radiation therapy on the outcomes of ileal pouches.
Methods: The study included 82 patients with IBD and ileal pouches, of whom 12 received pelvic radiation, 16 abdominal radiation, 14 radiation in other fields, and 40 served as controls with no radiation.
Revitalizing gut health: Liangxue guyuan yishen decoction promotes akkermansia muciniphila -induced intestinal stem cell recovery post-radiation in mice.
Phytomedicine
September 2024
Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, PR China; Medical College of Qinghai University, Xining, PR China; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, PR China; State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, PR China. Electronic address:
Article Synopsis
- Liangxue Guyuan Yishen Decoction (LGYD), a traditional Chinese medicine, has shown promising results in treating radiation-induced intestinal injury, but its mechanisms need further exploration for better understanding and potential pharmaceutical development.
- The study investigates how LGYD affects gut microbiota and short-chain fatty acids (SCFA) as part of its therapeutic effects on radiation-induced intestinal injury, utilizing various analytical methods to explore these relationships.
- Results indicate that LGYD enhances recovery from intestinal injury, boosts specific beneficial gut bacteria (like Akkermansia muciniphila), and increases SCFA levels, highlighting its potential as a treatment following high-dose radiation.
Genetic Upregulation of Activated Protein C Mitigates Delayed Effects of Acute Radiation Exposure in the Mouse Plasma.
Metabolites
April 2024
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.
Exposure to ionizing radiation, accidental or intentional, may lead to delayed effects of acute radiation exposure (DEARE) that manifest as injury to organ systems, including the kidney, heart, and brain. This study examines the role of activated protein C (APC), a known mitigator of radiation-induced early toxicity, in long-term plasma metabolite and lipid panels that may be associated with DEARE in APCHi mice. The APCHi mouse model used in the study was developed in a C57BL/6N background, expressing the D168F/N173K mouse analog of the hyper-activatable human D167F/D172K protein C variant.
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