The effect of ethanol on the subcellular distribution of Mn, Cu, Zn, Mg and Cr in rat liver has been investigated. Significant changes in Mg, Zn and Mn distribution have been observed. No change in the microsomal Mn, Cu, Zn, Mg and Cr content has been found.
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Inflammopharmacology
December 2024
Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100, Punjab, Pakistan.
Juice and decoction of leaves of Suaeda fruticosa, a halophytic medicinal plant of Cholistan desert, is traditionally used to treat rheumatism. The current study was carried out to probe into in vivo anti-nociceptive, anti-inflammatory, and anti-arthritic potential of ethanolic extract of the whole plant of S. fruticosa (Et-SF) and its bioactive molecules.
View Article and Find Full Text PDFFront Plant Sci
November 2024
College of Life and Environmental Sciences, Central South University of Forestry and Technology, Changsha, China.
Introduction: Arbuscular mycorrhizal fungi (AMF) can relieve manganese (Mn) phytotoxicity and promote plant growth under Mn stress, but their roles remain unclear.
Methods: In this study, inoculated with or without AMF () under different Mn concentrations (0 mmol/L, 1 mmol/L, 5 mmol/L, 10 mmol/L, and 20 mmol/L) was cultivated via a pot experiment, and plant biomass, physiological and biochemical characteristics, manganese absorption, subcellular distribution, and chemical forms of Mn were examined.
Results: The results showed that root biomass, stem biomass, leaf biomass, and total individual biomass decreased under high Mn concentrations (above 10 mmol/L), and the inoculated plants had higher biomass than the uninoculated plants.
J Agric Food Chem
December 2024
Department of Life Science, Chung-Ang University, Seoul 06974, South Korea.
The importance of nonconventional yeasts has increasingly been highlighted, particularly for aroma formation in fermented foods. Here, we performed whole-genome sequencing of , which produces a variety of volatile flavor compounds, leading to the identification of the alcohol acyltransferase (AATase) family of genes. The genome of contains seven AATase genes, encoding alcohol--acetyltransferases (ATFs) and ethanol acetyltransferase 1 (EAT1) for acetate ester formation, along with ethanol hexanoyl transferase 1 (EHT1) for ethyl ester formation.
View Article and Find Full Text PDFBiochem Biophys Res Commun
November 2024
Dept of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Ave. BSB 501 | MSC 509, Charleston, SC, 29425, USA; Dept of Regenerative Medicine and Cell Biology, Medical University of South Carolina, 173 Ashley Ave. BSB 501 | MSC 509, Charleston, SC, 29425, USA. Electronic address:
Chronic alcohol (ethanol) use is increasing in the United States and has been linked to numerous health issues in multiple organ systems including neurological dysfunction and diseases. Ethanol toxicity is mainly driven by the metabolite acetaldehyde, which is generated through three pathways: alcohol dehydrogenase (ADH2), catalase (CAT), and cytochrome P450 2E1 (CYP2E1). ADH2, while the main ethanol clearance pathway in the liver, is not expressed in the mammalian brain, resulting in CAT and CYP2E1 driving local metabolism of ethanol in the central nervous system.
View Article and Find Full Text PDFJ Cell Biol
December 2024
Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL, USA.
Cells maintain homeostasis via dynamic regulation of stress response pathways. Stress pathways transiently induce response regulons via negative feedback loops, but the extent to which individual genes provide feedback has not been comprehensively measured for any pathway. Here, we disrupted the induction of each gene in the Saccharomyces cerevisiae heat shock response (HSR) and quantified cell growth and HSR dynamics following heat shock.
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