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After JAK inhibitor failure: to cycle or to switch, that is the question - data from the JAK-pot collaboration of registries.
Ann Rheum Dis
February 2023
Division of Rheumatology, Department of Internal Medicine and Department of Medicine, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Objectives: The expanded therapeutic arsenal in rheumatoid arthritis (RA) raises new clinical questions. The objective of this study is to compare the effectiveness of cycling Janus kinase inhibitors (JAKi) with switching to biologic disease-modifying antirheumatic drug (bDMARD) in patients with RA after failure to the first JAKi.
Methods: This is a nested cohort study within data pooled from an international collaboration of 17 national registries (JAK-pot collaboration).
Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31 846 patients with rheumatoid arthritis in 19 registers from the 'JAK-pot' collaboration.
Ann Rheum Dis
October 2022
Division of Rheumatology, Department of Internal Medicine and Department of Medicine, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Background: JAK-inhibitors (JAKi), recently approved in rheumatoid arthritis (RA), have changed the landscape of treatment choices. We aimed to compare the effectiveness of four current second-line therapies of RA with different modes of action, since JAKi approval, in an international collaboration of 19 registers.
Methods: In this observational cohort study, patients initiating tumour necrosis factor inhibitors (TNFi), interleukin-6 inhibitors (IL-6i), abatacept (ABA) or JAKi were included.
Yeast cells immobilized in spherical gellan particles cross-linked with magnesium acetate.
J Biotechnol
October 2016
"Gheorghe Asachi" Technical University, Faculty of Chemical Engineering and Protection of the Environment, Department of Natural and Synthetic Polymers, 73 Prof.dr.docent Dimitrie Mangeron Street, 700050 Iasi, Romania; Academy of Romanian Scientists, Splaiul Independentei Str. 54, 050094 Bucuresti, Romania; Faculty of Dental Medicine, University "Apollonia", 3, Str. Muzicii, Iasi, Romania; Research Institute "Academician Ioan Haulica", 3, Str. Muzicii, Iasi, Romania. Electronic address:
In this paper we report on the production of microbioreactors using ionically cross-linked gellan containing immobilized yeast cells with potential application in glucose fermentation. Cross-linking was achieved through a novel extrusion process in capillary by ionotropic gelation under the action of magnesium acetate. Compared to commonly used methods, this provides a host of practical advantages.
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