The McCauley, a continuing care retirement community in West Hartford, CT, promotes a wellness philosophy that helps its residents retain their health and independence and extend their lives. The wellness program centers around the individual, not around the services provided. The residents have significant input and initiative in maintaining their own health. The health program is based on a nursing model, with each resident relating to a primary nurse as needs become evident. The nurses' goal is to know each person's holistic needs--to assist in maintaining physical, emotional, and spiritual balance. The program's approach to physical health requires a strong emphasis on prevention, including individualized fitness programs. The McCauley fosters mental and social well-being by allowing patients to maintain independent living for as long as they are able and by maximizing their self-direction. Another contributor to mental well-being is the opportunity for personal growth and intellectual stimulation. The McCauley promotes spiritual well-being by supporting continued participation in churches or synagogues from previous neighborhoods, fostering a supportive network within the community, and recognizing the value of residents' volunteer activities.
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Lancet Neurol
February 2025
Janssen Research & Development, a Johnson & Johnson Company, Titusville, NJ, USA.
Background: Given burdensome side-effects and long latency for efficacy with conventional agents, there is a continued need for generalised myasthenia gravis treatments that are safe and provide consistently sustained, long-term disease control. Nipocalimab, a neonatal Fc receptor blocker, was associated with dose-dependent reductions in total IgG and anti-acetylcholine receptor (AChR) antibodies and clinically meaningful improvements in the Myasthenia Gravis Activities of Daily Living (MG-ADL) scale in patients with generalised myasthenia gravis in a phase 2 study. We aimed to assess the safety and efficacy of nipocalimab in a phase 3 study.
View Article and Find Full Text PDFSci Total Environ
January 2025
Geology and Sustainable Mining Institute, Mohammed VI Polytechnic University, Lot 660, Hay Moulay Rachid, Ben Guerir 43150, Morocco.
In the face of the climate change crisis, circular economy (CE) is put forward as a promising key to the sustainable development goals (SDGs) riddle. In this context that affects developed and developing countries alike, circular initiatives arise, such is the case for Morocco where an industrial synergy based on the CE concept of 'waste is food' can be envisioned between the local phosphate and cement industries. In order to support and guide this initiative, a life cycle assessment (LCA) was conducted to compare the environmental performance of the production of ordinary Portland cement (OPC), limestone calcined clay cement (LC3) and a phosphate waste-based cement known as calcined marl cement (CMC).
View Article and Find Full Text PDFJ Bone Miner Res
January 2025
MRC Lifecourse Epidemiology Centre, Human Development and Health, University of Southampton, Southampton, United Kingdom.
HIV-related mortality has fallen due to scale-up of antiretroviral therapy (ART), so more women living with HIV (WLH) now live to reach menopause. Menopausal estrogen loss causes bone loss, as do HIV and certain ART regimens. However, quantitative bone data from WLH are few in Africa.
View Article and Find Full Text PDFAppl Microbiol Biotechnol
January 2025
Key Laboratory of Marine Ranching, Ministry of Agriculture and Rural Affairs, China, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, 510300, China.
The construction of artificial reefs (ARs) is an effective way to restore habitats and increase and breed fishery resources in marine ranches. However, studies on the impacts of ARs on the structure, function, and assembly patterns of the bacterial community (BC), which is important in biogeochemical cycles, are lacking. The compositions, diversities, assembly patterns, predicted functions, and key environmental factors of the attached and free-living microbial communities in five-year ARs (O-ARs) and one-year ARs (N-ARs) in Fangchenggang, China, were analyzed via 16S rRNA gene sequencing.
View Article and Find Full Text PDFNord J Psychiatry
January 2025
Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.
Purpose: People living in supported accommodation often have complex care needs, including longer-term mental health illness and physical health comorbidities. Effective coordination between health and supported accommodation services is crucial to address these needs. However, evidence on the effectiveness of healthcare interventions in this setting remains limited.
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