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Deciphering the Frailty Factor: Comprehensive Insights Into Its Impact on Postoperative Complications and Recovery Among Elderly Orthopedic Surgery Patients.
Indian J Orthop
February 2025
Department of Orthopaedics, Northern Railway Central Hospital, New Delhi, India.
Background: This single center-based prospective cohort study was conducted, on 157 patients over 60 years old patients requiring major orthopedic surgery, from June 2019 to June 2021. Frailty was assessed using the Edmonton Frailty Scale pre-operatively. Post-operative complications, ambulatory status, readmission rates, and mortality were monitored up to three months post-surgery, and statistical analysis was performed.
View Article and Find Full Text PDFBedside implications of the use of surrogate endpoints in solid and haematological cancers: implications for our reliance on PFS, DFS, ORR, MRD and more.
BMJ Oncol
October 2024
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
Clinical endpoints, such as overall survival, directly measure relevant outcomes. Surrogate endpoints, in contrast, are intermediate, stand-in measures of various tumour-related metrics and include tumour growth, tumour shrinkage, blood results, etc. Surrogates may be a time point measurement, that is, tumour shrinkage at some point (eg, response rate) or biomarker-assessed disease status, measured at given time points (eg, circulating tumour DNA, ctDNA).
View Article and Find Full Text PDFProspective evaluation of artificial intelligence (AI) applications for use in cancer pathways following diagnosis: a systematic review.
BMJ Oncol
May 2024
Institute of Cancer Policy, King's College London Faculty of Life Sciences & Medicine, London, UK.
The role of artificial intelligence (AI) in cancer care has evolved in the face of ageing population, workforce shortages and technological advancement. Despite recent uptake in AI research and adoption, the extent to which it improves quality, efficiency and equity of care beyond cancer diagnostics is uncertain to date. Henceforth, the objective of our systematic review is to assess the clinical readiness and deployability of AI through evaluation of prospective studies of AI in cancer care following diagnosis.
View Article and Find Full Text PDFInnovative therapeutic strategies for intrauterine adhesions: Role of umbilical cord mesenchymal stem cells in rat models.
Exp Ther Med
March 2025
Department of Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China.
Intrauterine adhesions (IUAs) represent a considerable impediment to female reproductive health. Despite ongoing debate regarding the optimally efficacious route of administration and dosage of stem cells for IUA treatment, human umbilical cord-derived mesenchymal stem cells (UCMSCs) have emerged as a promising avenue for regenerative therapy. The present study aimed to investigate the potential effects of UCMSCs on IUAs and to further explore the most effective treatment route and dosages.
View Article and Find Full Text PDFAims: The purpose of this research was to investigate to what extent the most commonly identified non-native features in the L1 speech of late consecutive bilinguals are reflected in differences in the bilinguals' productions of these features compared with those of monolingual speakers of the L1.
Design: We investigated the L1 accent of English migrants to Austria and monolingual English speakers in the United Kingdom in two inter-related studies.
Data: In Study 1, an accent-perception experiment, native English listeners rated the nativeness of the monolinguals' and bilinguals' L1 English productions of read sentences, using a 6-point scale, and subsequently commented on the accentual features associated with perceived non-nativeness.
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