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The role of α-tocopherol in the prevention and treatment of Alzheimer's disease.
Mol Cell Biochem
January 2025
Department of Clinical Biochemistry and Laboratory Diagnostics, Institute of Medical Sciences, University of Opole, Oleska 48, 45-052, Opole, Poland.
Scientific reports from various areas of the world indicate the potential role of tocopherols (vitamin E) in particular α-tocopherol in the prevention and therapy of Alzheimer's disease. The current phenomenon is related to the growing global awareness of eating habits and is also determined by the need to develop the prevention, management and therapy of Alzheimer's disease. This article is a review of current research on the action of the active form of vitamin E-α-tocopherol and its impact on the development and course of Alzheimer's disease.
View Article and Find Full Text PDFFluopyram analogues containing an indole moiety: synthesis, biological activity and molecular docking study.
Mol Divers
January 2025
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, People's Republic of China.
Succinate dehydrogenase (SDH) has been identified as one of the ideal targets for the development of novel nematicides. However, the resistance of nematodes to fluopyram, one of the commercialized SDH inhibitors, is becoming a growing concern. Since expanding the structural diversity around an active scaffold is a useful strategy for drug development, herein a series of fluopyram analogues with a broad, biologically relevant indole moiety were synthesized and evaluated for nematicidal activity against C.
View Article and Find Full Text PDFResource Segmentation: A New Dimension of the Segmentation Hypothesis in Drought Adaptive Strategies and Its Links to Tree Growth Performance.
Plant Cell Environ
January 2025
Qianyanzhou Ecological Research Station, Key Laboratory of Ecosystem Network Observation and Modeling, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, China.
The segmentation hypothesis, a framework for understanding plant drought adaptive strategy, has long been based on hydraulic resistance and vulnerability. Storage of water and carbohydrate resources is another critical function and shapes plant drought adaption and fitness together with hydraulic efficiency and vulnerability. However, patterns and implications of the interdependency of stored water and carbohydrate resources in the context of the segmentation hypothesis are poorly understood.
View Article and Find Full Text PDFCovariate Model Selection Approaches for Population Pharmacokinetics: A Systematic Review of Existing Methods, From SCM to AI.
CPT Pharmacometrics Syst Pharmacol
January 2025
Pharmacokinetics Dynamics and Metabolism/Translational Medicine and Early Development, Sanofi R&D Montpellier, Montpellier, France.
A growing number of covariate modeling methods have been proposed in the field of popPK modeling, but limited information exists on how they all compare. The objective of this study was to perform a systematic review of all popPK covariate modeling methods, focusing on assessing the existing knowledge on their performances. For each method of each article included in this review, evaluation setting, performance metrics along with their associated values, and relative computational times were reported when available.
View Article and Find Full Text PDFSlow-Release Pharmaceutical Implants in Ecotoxicology: Validating Functionality across Exposure Scenarios.
ACS Environ Au
January 2025
Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences, Umeå SE-907 36, Sweden.
Pharmaceutical contaminants have spread in natural environments across the globe, endangering biodiversity, ecosystem functioning, and public health. Research on the environmental impacts of pharmaceuticals is growing rapidly, although a majority of studies are still conducted under controlled laboratory conditions. As such, there is an urgent need to understand the impacts of pharmaceutical exposures on wildlife in complex, real-world scenarios.
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