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Acute arsenic exposure induces cyto-genotoxicity and histological alterations in Labeo rohita.
J Trace Elem Med Biol
January 2025
Department of Fisheries and Aquaculture, University of Veterinary and Animal Sciences, Lahore, Pakistan. Electronic address:
Background: Arsenic emerges as most potent hazardous element ranked as number one in ATSDR (Agency for Toxic Substances and Disease Registry) list, can easily accumulate in fish, transported to humans via consumption and affect humans and aquatic organisms. Considering above, current experiment designed to evaluate cyto-genotoxicity and histological alterations induced by arsenic in Labeo rohita used as an animal model.
Methods: By applying complete randomized design sampling acclimatized individuals of Labeo rohita (10 batches of 10 each with triplicates) were exposed to nine definitive doses (12, 14, 16, 18, 20, 22, 24, 26 and 28 mgL) of arsenic in glass aquaria to determine 96-h lethal concentration (LC) of arsenic.
Enhanced spatial analysis assessing the association between PFAS-contaminated water and cancer incidence: rationale, study design, and methods.
BMC Cancer
January 2025
Research Triangle Institute, International, Cary, North Carolina, United States.
Background: Cancer is a complex set of diseases, and many have decades-long lag times between possible exposure and diagnosis. Environmental exposures, such as per- and poly-fluoroalkyl substances (PFAS) and area-level risk factors (e.g.
View Article and Find Full Text PDFAssessment of organochlorine pesticide residues in agricultural soils of southern Nigeria and analysis of potential health risks.
Toxicol Rep
December 2024
Lancaster Environment Centre, Lancaster University, Lancaster LA1 4YQ, UK.
The use of pesticides in commercial farms can lead to exposure among various vulnerable groups. This study assessed the distribution, human health risks, and origins of 13 targeted organochlorine pesticides (OCPs) in soil samples from commercial farms in Southern Nigeria. Following a questionnaire survey on pesticide usage, soil samples were subjected to Soxhlet extraction and analyzed using gas chromatography-mass spectrometry.
View Article and Find Full Text PDFAnalysis of EPA air toxics monitoring data and tools for use in general population exposure assessments: Using acrylonitrile as a case study.
J Air Waste Manag Assoc
January 2025
Exposure Sciences Practice, ToxStrategies LLC, Pittsburgh, Pennsylvania, USA.
Acrylonitrile (AN) is a vinyl monomer used in the manufacture of polymers that have a wide variety of applications in the industrial, consumer, and automotive realms. Acrylonitrile was recently proposed to be designated as a high-priority substance for risk evaluation by the U.S.
View Article and Find Full Text PDFThe Role of Simulation Science in Public Health at the Agency for Toxic Substances and Disease Registry: An Overview and Analysis of the Last Decade.
Toxics
November 2024
Office of Innovation and Analytics, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30329, USA.
Article Synopsis
- Environmental exposures are common and significantly affect public health, leading to chronic and infectious diseases, but there's a lack of comprehensive data on the health impacts of these contaminants.
- Simulation science has emerged as a solution to address data gaps by using computational methods like PBPK modeling and QSAR modeling to assess environmental health risks more efficiently.
- The ATSDR (Agency for Toxic Substances and Disease Registry) effectively utilizes these simulation tools, gaining recognition from external researchers and collaborating across various sectors to enhance public health protection.
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