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Overlooked Carbamazepine Toxicity: A Diagnostic Pitfall in an Elderly Patient With Dizziness.
Cureus
February 2025
Center for General Medicine Education, School of Medicine, Keio University, Tokyo, JPN.
Dizziness is a common chief complaint that often poses a diagnostic challenge. A 79-year-old man was initially misdiagnosed with peripheral vertigo based on normal neuroimaging but later developed altered consciousness and involuntary limb movements, ultimately revealing carbamazepine (CBZ) toxicity. This case highlights a critical diagnostic pitfall: prematurely attributing dizziness to peripheral vertigo without considering drug-induced syndromes.
View Article and Find Full Text PDFEnvironmental implications of SiBN nanoflakes in pharmaceutical pollutant detection and removal: insights from first-principle calculations.
Sci Rep
March 2025
Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt.
Pharmaceutical pollutants, such as carbamazepine (CBZ), are emerging contaminants that pose significant environmental and health risks due to their persistence in aquatic ecosystems and incomplete removal by conventional wastewater treatments. This study leverages density functional theory (DFT), a gold-standard computational quantum mechanical modeling method, to evaluate the efficacy of SiBN nanoflakes-a novel two-dimensional material-for CBZ adsorption and detection. Our first-principles calculations reveal thermodynamically stable interactions between CBZ and SiBN, with adsorption energies of - 0.
View Article and Find Full Text PDFEvaluation of antiseizure medication concentration ranges in blood samples using an automated big data approach.
Epilepsia
March 2025
Department of Clinical Biochemistry, Holbæk Hospital, Holbæk, Denmark.
Objective: The aim of the study is to provide insight into the real-world use of therapeutic drug monitoring (TDM) for the most common antiseizure medications (ASMs).
Methods: In total, 137 586 samples from the period 2019-2023 were collected from the five main Danish laboratories performing TDM. A previously described algorithm developed to exclude abnormal TDM results from patient data was applied.
Comparative risk of major health events among individuals prescribed different antiseizure medications following ischemic stroke.
Epilepsia
March 2025
Centre for Medicine Use and Safety, Monash University, Melbourne, Victoria, Australia.
Objective: The aim of this study was to compare the risk of seizure, recurrent stroke, fall or fracture, and mortality in individuals prescribed different antiseizure medications (ASMs) following an ischemic stroke.
Methods: We identified all patients admitted to a Victorian public or private hospital with a principal diagnosis of an incident ischemic stroke between 2013 and 2017 and dispensed an ASM within 12 months of discharge. Cox proportional hazards regression was used to estimate the risk of cause-specific rehospitalization or emergency department visits (seizure, fall or fracture, recurrent stroke) and all-cause mortality over a 2-year period.
Novel ultrathin Bi@Fe-based metal-organic frameworks nanosheets for efficient solar-driven photocatalytic water purification: Synergistic effect of localized surface plasmon resonance and high-density exposed metal active centers.
J Colloid Interface Sci
March 2025
National Engineering Research Center of Industrial Wastewater Detoxication and Resource Recovery, East China University of Science and Technology, Shanghai 200237, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200237, China. Electronic address:
Fe-based metal-organic frameworks (Fe-MOFs) have been extensively studied as fascinating photocatalysts due to their tunable structure and appealing light response. However, the application of traditional three-dimensional (3D) Fe-MOFs is limited by rapid carrier recombination and inaccessible active sites. In this work, a novel two-dimensional (2D) Bi decorated Fe-MOFs nanosheet photocatalyst was constructed, which exhibits significantly enhanced solar-driven photocatalytic activity due to the synergistic effect of localized surface plasmon resonance (LSPR) and surface high-density exposed metal active sites.
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