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Impact of Patient-Specific Hip Joint Geometry on the Morphology of Acetabular Fractures.
J Clin Med
December 2024
Clinic for Orthopedics and Trauma Surgery, University Hospital of Bonn, 53127 Bonn, Germany.
: Acetabular fractures continue to pose a major challenge in clinical practice, not least because of the growing geriatric population. While the influence of the force vectors on fracture formation is well established, the impact of anatomical factors on fracture morphology remains poorly understood. The aim of this study was to investigate patient-specific hip joint geometry, identify structural risk factors and correlate these with the resulting fracture patterns.
View Article and Find Full Text PDFA new classification system for distal clavicle fractures: based on fracture location and ligament integrity.
Arch Orthop Trauma Surg
December 2024
Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu, 210029, People's Republic of China.
Introduction: Although various classification systems have been introduced for the description of distal clavicle fractures, there is no consensus on the best classification system that is helpful in determining treatment and prognosis. The objective of this study was to establish a new classification system for distal clavicle fractures and to verify the reliability of the new classification system by evaluating the inter- and intraobserver agreement.
Materials And Methods: A total of 1075 consecutive patients with distal clavicle fractures were selected from five university-affiliated hospitals between 2012 and 2022.
Evaluating the association of radiographic parameters of proximal humerus fractures managed conservatively with functional outcomes.
Arch Orthop Trauma Surg
August 2024
Department of Orthopaedic Surgery, Woodlands Health Campus, Singapore, Singapore.
Introduction: Treatment of proximal humerus fractures remains controversial. Understanding the factors that can affect the long-term functional outcomes can aid with management choices. This primary aim of this paper is to evaluate the association of radiographic parameters with functional outcomes.
View Article and Find Full Text PDFHip Axis Length and Femoral Neck-Shaft Angle as Risk Factors for Proximal Femur Fractures in Octogenarians to Centenarians.
J Clin Med
July 2024
Clinic for Orthopaedics, Trauma Surgery and Hand Surgery, Stadtspital Zürich, Tièchestrasse 99, 8037 Zürich, Switzerland.
(1) : The prevention of proximal femoral fractures among people of very advanced age is relevant as they are common and increasing in number. The aim of this study was to determine if the hip axis length (HAL) and the neck-shaft angle (caput-collum-diaphyseal CCD) are risk factors for those fractures among people aged 80 years and over. Consequently, it was additionally analysed if these parameters are associated with a certain fracture type.
View Article and Find Full Text PDFSpexin Diminishes Atrial Fibrillation Vulnerability by Acting on Galanin Receptor 2.
Circulation
July 2024
National Key Laboratory of Frigid Zone Cardiovascular Diseases, Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, International Cooperation Base for Major Cardiovascular Diseases in Cold Regions, China) College of Pharmacy (D.L., Changzhu Li, Z.Z., K.G., H.B., J.Y., K.S., L. Zhang, J.L., Chenhong Li, J.S., L. Zhao, Y.P., L.X., Y.Z., Y. Lu, B.Y., Z.P.), First Affiliated Hospital, Harbin Medical University, China.
Article Synopsis
- G protein-coupled receptors, especially galanin receptors (GALRs), are significant in understanding atrial fibrillation (AF), with spexin identified as a unique ligand affecting these receptors.
- Research involving genetically modified mice showed that the absence of spexin increased the likelihood of AF and disrupted potassium currents and calcium handling in heart cells.
- The study concluded that spexin lowers AF risk by inhibiting the phosphorylation of CREB, leading to decreased expression of specific channels and improved cardiac function.
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