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Development of Graves' disease after subacute thyroiditis: two unusual cases.
Acta Endocrinol (Copenh)
June 1992
Kuma Hospital, Kobe, Japan.
This report describes two unusual cases of subacute thyroiditis from which Graves' disease with hyperthyroidism developed seven to eight years after complete recovery. The first case is a 45-year-old woman who developed hyperthyroidism seven years after recovering from subacute thyroiditis. This patient had a genetic predisposition to both subacute thyroiditis HLA-BW35 and Graves' disease (HLA-BW46).
View Article and Find Full Text PDFThe occurrence of permanent overt hypothyroidism (POH) following subacute thyroiditis (SAT) was studied in 103 patients during 11-142 months (mean 52.8 months). Increased amount of plasma cells in cytological pictures of goitre aspirates was found at the time of diagnosis of SAT in 25 cases (24.
View Article and Find Full Text PDFUnlabelled: Despite the fact that subacute thyroiditis (SAT) is a common disease, its pathogenesis is still uncertain. At present, viral infection is simply thought to be a possible pathogenic factor. In Caucasians and Chinese, however, a strong association has recently been found between HLA-Bw35 and SAT.
View Article and Find Full Text PDFThe HLA antigens in 40 patients with subacute thyroiditis were investigated. An association between subacute thyroiditis and HLA-Bw35 antigen as previously reported, was confirmed. Further immunological observations included a decrease in Serum Clq, C4 and C3 activator levels; conversely, there was an increase in serum C3, IgM, alpha1-acid glycoprotein and alpha1-antitrypsin levels.
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