The action of a single toxic dose of 2-acetylaminofluorene or allylic alcohol on the adrenals. I. Behaviour of organ weight and mitotic activity of the adrenocortical cells.

In male Sprague-Dawley rats the relative organ weight and mitotic activity of the adrenal cortex were investigated after intoxication by a single dose of 200 mg/kg b.w. of 2-acetylaminofluorene (AAF) or 20 mg/kg b.w. of allylic alcohol (ALL). 36, 42, 48 and 72 hours after application a significant enhancement of the mitotic rate of the adrenocortical cells was produced by AAF in comparison with that following ALL administration. Interrelations of organ weight and proliferative activity could not be found.