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Characteristics of neutrophil chemotaxis in bottlenose dolphin (Tursiops truncatus).
Vet Immunol Immunopathol
February 2025
Laboratory of Preventive Veterinary Medicine and Animal Health, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa-ken 252-0880, Japan. Electronic address:
Cetaceans have adapted to aquatic life by evolving various anatomic and physiologic traits, but biological defense mechanisms specific to aquatic mammals that protect against pathogenic microorganisms in the aquatic environment have not been elucidated. In this study, we investigated the migration of polymorphonuclear leukocytes in bottlenose dolphins in response to various chemotactic factors and compared the migration response with that of terrestrial animals such as cows and humans to characterize biological defense mechanisms unique to cetaceans. Bottlenose dolphin neutrophils showed strong chemotactic activity toward zymosan-activated serum and recombinant human interleukin-8 but no chemotaxis toward N-formyl-methionyl-leucyl-phenylalanine or leukotriene B at any concentration examined.
View Article and Find Full Text PDFComparative analysis of the specificity of monoclonal antibodies developed against the bottlenose dolphin, Tursiops truncatus, TNF-α, IL1-β, IL-6, IL-8, IL-10 with monoclonal antibodies made against ovine IFN-γ bovine IL-17A and IL-1β revealed they recognize epitopes conserved on dolphin and bovine orthologues.
Vet Immunol Immunopathol
August 2022
Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, WA, USA. Electronic address:
Opportunities to include Cetancodontamorpha in the study of the evolution of the immune system in the clades of Artiodactylamorpha, Ruminantiamorpha, Suinamorpha, and Camelidamorpha have increased with the use of the bottlenose dolphin, Tursiops truncatus, as a sentinel species to study the effects of environmental pollutants on the health of marine mammals. Efforts are currently underway to increase the number reagents needed for detailed studies. Thus far, screening of monoclonal antibodies (mAbs) made to leukocyte differentiation molecules (LDM) and the major histocompatibility (MHC) class I and class II molecules in Ruminantiamorpha have yielded some mAbs that recognize conserved epitopes expressed on orthologues in the bottlenose dolphin.
View Article and Find Full Text PDFA transcriptomic analysis of the stress induced by capture-release health assessment studies in wild dolphins (Tursiops truncatus).
Mol Ecol
June 2008
Marine Biomedicine and Environmental Science Center, Medical University of South Carolina, 221 Fort Johnson Road, Charleston, SC 29412, USA.
The health of wild bottlenose dolphins (Tursiops truncatus) is typically evaluated by the study of animals that are captured and released back into the wild after examination. The impact of such studies on gene expression in peripheral blood cells was investigated using microarray and quantitative polymerase chain reaction methods. Significantly increased expression was observed in two major classes of genes: (i) energy metabolism, and (ii) responsiveness to stress and trauma, the latter effect suggesting the initiation of an acute-phase response.
View Article and Find Full Text PDFMolecular cloning and expression of bottlenose dolphin (Tursiops truncatus) interleukin-8.
J Vet Med Sci
December 2003
Department of Preventive Veterinary Medicine and Animal Health, Nihon University School of Veterinary Medicine, Kanagawa, Japan.
The bottlenose dolphin interleukin (IL)-8 cDNA was molecularly cloned. The dolphin IL-8 has an open reading frame of 303-bp encoding 101 amino acids. The homology of the amino acid sequence with that of other species was: sheep, 89.
View Article and Find Full Text PDFDolphin interleukin-8 receptor. Map position 18q25-26.
Chromosome Res
December 1998
Department of Anatomy and Public Health, College of Veterinary Medicine, Texas A&M University, College Station 77843, USA.
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