In 67 patients with ischemic and hemorrhagic strokes the authors studied the histamine metabolism in its development correlating the observed changes (in the acute stage of the disease and following medicative therapy). The results demonstrated that in the acute period of the disease the histamine content in the blood increases, while the histaminase activity and the histaminpexic index decreases. It was shown that these changes are more distinct in hemorrhagic strokes. In extensive processes involving the subcortical nodes, the internal capsule and hypothalamus, these parameters show deeper changes and in the future do not normalize. Such studies may be of topico-diagnostic importance as well as of prognostic and therapeutical significance.
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