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Long-term heart transplant outcomes after lowering fixed pulmonary hypertension using left ventricular assist devices.
Eur J Cardiothorac Surg
December 2018
Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
Article Synopsis
- Fixed pulmonary hypertension (fPH) is a challenge for heart transplantation (HTX), but left ventricular assist devices (LVADs) can help reverse it in patients with severe heart failure, allowing them to become candidates for HTX.* -
- This study reviewed 79 patients who received LVADs for terminal heart failure and fPH from 1998 to 2016, finding a significant decrease in pulmonary vascular resistance after LVAD implantation and a median support duration of 288 days before they were eligible for transplant.* -
- Post-transplant outcomes showed similar survival rates between those bridged to HTX with LVADs and a control group, suggesting that LVAD implantation effectively prepares patients with fPH for successful heart transplantation
Durable left ventricular assist device therapy in advanced heart failure: Patient selection and clinical outcomes.
Indian Heart J
April 2016
Center for Advanced Heart Disease, Brigham and Women's Hospital Heart and Vascular Center, Boston, MA, United States; Harvard Medical School, Boston, MA, United States. Electronic address:
The increasing adoption of left ventricular assist devices (LVADs) into clinical practice is related to a combination of engineering advances in pump technology and improvements in understanding the appropriate clinical use of these devices in the management of patients with advanced heart failure. This review intends to assist the clinician in identifying candidates for LVAD implantation, to examine long-term outcomes and provide an overview of the common complications related to use of these devices.
View Article and Find Full Text PDFCerebrovascular complications of left ventricular assist devices.
Eur J Cardiothorac Surg
October 2012
Department of Intensive Care Medicine, University Medical Centre Utrecht, Utrecht, Netherlands.
Left ventricular assist devices (LVADs) are increasingly being used as a bridge to heart transplantation or destination therapy. It is unclear which antithrombotic regimen should be used to reduce the risk of stroke. We systematically reviewed the literature on all types of antithrombotic regimens and stroke in patients with any type of LVADs.
View Article and Find Full Text PDFAvoiding technical pitfalls in left ventricular assist device placement.
Cardiol Clin
November 2011
Section of Cardiac Surgery, Yale University School of Medicine, New Haven, CT 06510, USA.
Left ventricular assist device (LVAD) placement is a serious surgical procedure. At our center, we accumulated a very large experience with the Novacor LVAD from the very first clinical trial, as well as from more recent experiences with the Jarvik 2000 and the HeartMate II. This article discusses technical issues that are common to all durable LVAD devices, with special emphasis on strategy and technical considerations aimed at avoiding surgical pitfalls.
View Article and Find Full Text PDFMechanical circulatory support as a bridge to transplant candidacy.
J Card Surg
September 2011
Heart Transplant Program, Peter Munk Cardiac Center, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada.
Introduction: The use of mechanical circulatory support (MCS) in nontransplant eligible candidates remains controversial. Our decision to offer MCS for nontransplant candidates has led to their reevaluation after a period of left ventricular assist device (LVAD) support.
Methods: From 2001 to September 2009, we had 37 patients who received an implantable LVAD, 22 (59%) were not deemed to be transplant eligible at the time of LVAD insertion (bridge to candidacy, BTC group).
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