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Metformin radiosensitizes OSCC in 2D and 3D models: possible involvement of CAF-1.
Pathologica
December 2024
Department of Pharmacy, University of Salerno, Italy.
Objective: This study investigated metformin as a sensitizer for radiotherapy in oral squamous cell carcinoma (OSCC) to reduce the radiation intensity. It evaluated the drug's effect on Chromatin Assembly Factor-1 (CAF-1) expression, whose high levels correlate with worse prognosis of this cancer.
Methods: The effects of metformin, alone and with radiotherapy, were evaluated on CAL27 (HPV-) and SCC154 (HPV+) OSCC cells.
EVOLUTION OF METFORMIN IN BREAST CANCER THERAPY IN LAST TWO DECADES: A REVIEW.
Exp Oncol
December 2024
Department of Medical Oncology, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Kattankulathur, Tamilnadu, India.
Among women, breast cancer is one of the most prevalent cancers. The disease has a complex etiology, with multiple biological pathways contributing to its development. As insulin signaling has mitogenic effects, glucose is a necessary cellular metabolic substrate, and the growth and metastasis of breast cancer are closely related to cellular glucose metabolism.
View Article and Find Full Text PDFMetformin efficacy and safety as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double-blind, placebo-controlled trial.
J Psychopharmacol
December 2024
Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Background: Antidiabetic medications have shown efficacy in alleviating autism symptoms. However, there is a lack of clinical research on the impact of metformin on irritability associated with autism. This study aimed to assess the efficacy and safety of metformin as an adjuvant therapy with risperidone for managing irritability in children diagnosed with Autism Spectrum Disorder (ASD).
View Article and Find Full Text PDFAnalysis of tumoral, stromal and glycolitic markers in the response basal cell carcinoma and Bowen disease to photodynamic therapy in real life.
Photodiagnosis Photodyn Ther
December 2024
Department of Dermatology, Miguel Servet University Hospital, University of Zaragoza, IIS Aragón. Zaragoza, Spain.
Background: Photodynamic therapy (PDT) is a widely-used non-surgical treatment for non-melanoma skin cancers, including basal cell carcinoma (BCC), actinic keratoses (AK), and Bowen's disease (BD). PDT has high success rates, but various factors, can influence treatment response. This study investigates the clinical, histological, and molecular factors that affect the efficacy of methyl aminolevulinate PDT (MAL-PDT) for BCC and BD.
View Article and Find Full Text PDFHypoglycemic Activity of the Hydroalcoholic Extract of in CD1 Mice.
J Med Food
November 2024
Área Académica de Medicina Veterinaria y Zootecnia, Instituto de Ciencias Agropecuarias, Universidad Autónoma del Estado de Hidalgo, Tulancingo, México.
Article Synopsis
- Diabetes is a major health issue in Mexico, caused by issues with insulin production or usage, leading to high blood sugar and damage to organs if uncontrolled.
- A study evaluated the hypoglycemic effects of a hydroalcoholic extract from certain plant aerial parts (HEPr) on blood sugar levels in mice, showing significant improvements compared to control and metformin groups.
- The beneficial effects of HEPr are linked to its content of compounds like chlorogenic acid and quercetin, making it a potentially valuable addition to managing chronic diseases related to diabetes.
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