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Intracavitary cisplatin-fibrin followed by irradiation improved tumor control compared to the single treatments in a mesothelioma rat model.
JTCVS Open
December 2024
Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.
Objective: To test the safety and efficacy of combination treatment for pleural mesothelioma (PM) with intracavitary cisplatin-fibrin (cis-fib) plus hemithoracic irradiation (IR) applied after lung-sparing surgery in an orthotopic immunocompetent rat model.
Methods: We randomized male F344 rats into 5 groups: cis-fib (n = 9), 10 Gy IR (n = 6), 20 Gy IR (n = 9), cis-fib+10 Gy IR (n = 6), and cis-fib+20 Gy IR (n = 9). Subpleural tumor implantation was performed on day 0 with 1 million syngeneic rat mesothelioma cells (IL45-luciferase).
Development and In-Vitro Evaluation of Doxorubicin-Loaded Methacrylate Gelatin (GelMa)-Acrylamide Hydrogels for the Treatment of Malignant Pleural Mesothelioma.
Pharm Res
December 2024
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY, 11439, USA.
Article Synopsis
- The study focuses on malignant pleural mesothelioma (MPM), a serious lung cancer, and investigates a new method to deliver the chemotherapy drug Doxorubicin using a specially developed hydrogel, aiming to improve treatment efficacy.
- The hydrogel, which combines GelMa and acrylamide, shows promising physical properties such as quick gelling, high swelling, and easy injectability, while effectively releasing Dox over 12 days without compromising its effectiveness.
- In cell studies, the Dox-loaded hydrogels outperform plain Dox in reducing tumor growth, demonstrating significant potential for localized chemotherapy in treating MPM.
Management of COVID-19 Infection Associated Lung Abscess with Secondary Pleural Empyema Using Percutaneous Intracavitary Drainage: Case Series and Review of the Literature.
J Clin Med
November 2024
Thoracic Surgery Clinic, Leon Daniello Clinical Hospital of Pneumology, 400371 Cluj-Napoca, Romania.
: COVID-19-related pulmonary complications, such as lung abscesses and pleural empyema, are rare but serious. This study presents a case series of three patients with COVID-19-associated lung abscesses complicated by pleural empyema, managed conservatively with percutaneous intracavitary drainage (ICD) and lavage. We assess the efficacy and safety of this treatment and compare our findings with the current literature.
View Article and Find Full Text PDFSuccessful Medical Management of Pulmonary Gangrene in a Transplanted Lung.
Transplant Proc
November 2024
William S. Middleton Veterans Hospital, Lung Transplant Program Madison, Madison, Wisconsin; University of Wisconsin School of Medicine, Lung Transplant Program Madison, Madison, Wisconsin.
Article Synopsis
- Pulmonary gangrene (PG) can occur as a severe complication of necrotizing pneumonia, particularly in lung transplant patients.
- A patient showed pneumonia symptoms, and tests revealed multiple bacterial infections, prompting customized antibiotic treatment.
- The patient responded well to extended antibiotic therapy, leading to both clinical improvement and resolution of the lung tissue damage seen on imaging.
Antigen targeting and anti-tumor activity of a novel anti-CD146 Pb internalizing alpha-radioimmunoconjugate against malignant peritoneal mesothelioma.
Sci Rep
October 2024
Oncoinvent ASA, 0484, Oslo, Norway.
Malignant mesothelioma, a highly aggressive cancer that primarily affects the serosal membranes, has limited therapeutic options, particularly for cavitary tumors, such as peritoneal and pleural malignant mesothelioma. Intracavitary administration of a radioimmunoconjugate to locally target mesothelioma cancer cells has been proposed as a treatment. CD146, upregulated in mesothelioma but not in healthy tissues, is a promising therapeutic target.
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