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Metabolic engineering of Yarrowia lipolytica for the production and secretion of the saffron ingredient crocetin.
Biotechnol Biofuels Bioprod
January 2025
Department of Bioengineering, Imperial College Centre for Synthetic Biology, Bezos Centre for Sustainable Protein, UKRI Engineering Biology Mission Hub on Microbial Food, Imperial College London, London, SW7 2AZ, UK.
Background: Crocetin is a multifunctional apocarotenoid natural product derived from saffron, holding significant promises for protection against various diseases and other nutritional applications. Historically, crocetin has been extracted from saffron stigmas, but this method is hindered by the limited availability of high-quality raw materials and complex extraction processes. To overcome these challenges, metabolic engineering and synthetic biology can be applied to the sustainable production of crocetin.
View Article and Find Full Text PDFChemical Composition and Assessment of the Anti-Inflammatory, Antioxidant, Cytotoxic and Skin Enzyme Inhibitory Activities of (L.) Osbeck Essential Oil and Its Major Compound Limonene.
Pharmaceuticals (Basel)
December 2024
Laboratory of Microbial Biotechnology and Bioactive Molecules, Faculty of Sciences and Technologies, Sidi Mohamed Ben Abdellah University, Imouzzer Road, Fez 30000, Morocco.
Essential oils (EOs) from species have attracted attention for their diverse properties, including anti-inflammatory, antioxidant and cytotoxic effects, which address critical health challenges such as chronic diseases and skin disorders. (L.) Osbeck, which is a widely cultivated citrus fruit, is attracting increasing attention in the field of medicinal research due to its richness of limonene (comprising approximately 85-90% of the oil).
View Article and Find Full Text PDFSustainable Carotenoid Extraction from Macroalgae: Optimizing Microwave-Assisted Extraction Using Response Surface Methodology.
Life (Basel)
November 2024
REQUIMTE/LAQV, ISEP, Polytechnic of Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal.
This study aimed at optimizing carotenoid extraction using the macroalga (L.) S.F.
View Article and Find Full Text PDFBioactive Compounds, Antioxidant Properties, and Antimicrobial Profiling of a Range of West Algerian Honeys: In Vitro Comparative Screening Prior to Therapeutic Purpose.
Foods
December 2024
Department of Analysis and Food Quality Assessment, University of Life Sciences in Lublin, 8 Skromna Str., 20-704 Lublin, Poland.
Honey is a complex natural nutrient with well-established therapeutic properties recognized in traditional medicine. The purpose of the current work was to compare, in vitro, the bioactive compounds, antioxidants, and antimicrobial properties of 37 honey samples collected from the western region of Algeria and to identify the best sample for potential therapeutic purposes. Estimation of bioactive compounds was carried out by determining the total phenolic and flavonoid contents.
View Article and Find Full Text PDFChanges in Carotenoids and Quality Parameters of Sweet Paprika () After an Accelerated Heat Treatment.
Antioxidants (Basel)
December 2024
Department of Food Technology, Food Science and Nutrition, University of Murcia, Campus of International Excellence "Campus Mare Nostrum", 30100 Murcia, Spain.
Paprika, obtained from dried red pepper (), is valued for its characteristic colour and flavour. Its carotenoid content, which is important for both sensory and nutritional quality, varies depending on several factors (agronomic conditions and technological treatment with special attention to the drying methods) that influence the colour and antioxidant capacity of the samples. This study investigated the effect of an accelerated thermal treatment (80 °C for 8 h) applied to evaluate the oxidative stability of the carotenoids and the colour of ground paprika depending on its origin (Peru or China).
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