We have characterized a novel type of non-coding RNA which consists of tandem repeats of similar sequences, approximately 0.9 kb in size. This RNA, termed Bsr (brain specific repetitive) RNA, is encoded at a single locus (6 q31-->q32) in the rat genome, where 100 to 150 copies of the 0.9 kb sequences are repeated in tandem. Bsr RNA is preferentially expressed in the rat central nervous system (CNS), especially in phylogenetically old structures, such as the pareo- and archicortex, amygdala, thalamus and hypothalamus. In the developing brains, Bsr RNA is expressed in the subsets of differentiating cells but not in proliferating cells. Despite the finding that Bsr RNA appears to be conserved only among the Rattus species, the specific expression pattern of Bsr RNA suggests that it might have some role in the rat CNS.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0169-328x(98)00343-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fine mapping of the Chilli veinal mottle virus resistance 4 (cvr4) gene in pepper (Capsicum annuum L.).
Theor Appl Genet
January 2025
Department of Agriculture, Forestry and Bioresources, Research Institute of Agriculture and Life Sciences, Plant Genomics and Breeding Institute, College of Agriculture and Life Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
The single recessive Chilli veinal mottle virus resistance locus, cvr4, was fine-mapped in pepper through bulked segregant RNA sequencing combined with gene silencing analysis. Chilli veinal mottle virus (ChiVMV) is a widespread pathogen affecting the production of peppers (Capsicum annuum L.) in Asia and Africa.
View Article and Find Full Text PDFMolecular identification of a Pm4 allele conferring powdery mildew resistance in durum wheat DR88.
BMC Plant Biol
December 2024
Center for Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang, 050022, China.
Article Synopsis
- Powdery mildew, caused by Blumeria graminis f. sp. tritici, is a highly destructive disease impacting wheat, particularly affecting common wheat, but durum wheat serves as a key resource for enhancement efforts.* -
- The study identified a durum wheat variety (DR88) with strong resistance to powdery mildew, localizing the dominant resistance gene, PmDR88, to a specific region on chromosome arm 2AL and confirming its association with the Pm4 locus through extensive genotyping.* -
- Despite PmDR88 sharing amino acid sequences with the Pm4d allele, it has distinct expression patterns; two complementary DNA markers were developed for efficient marker-assisted selection to integrate this
Gene silencing of Histidyl-tRNA synthetase in Leishmania donovani promastigotes inhibits parasite growth and reduces virulence: A comprehensive computational and in vitro study.
Microb Pathog
January 2025
Department of Biotechnology, Panjab University, Sector-25, South Campus, Chandigarh, 160025, India.
Article Synopsis
- * Histidyl-tRNA synthetase (HisRS) is a vital enzyme for the growth and survival of Leishmania donovani, as shown by significant reductions in its mRNA levels and parasite virulence when silenced using RNA interference (siRNA).
- * Halofuginone emerged as a promising potential inhibitor for LdHisRS, demonstrating strong binding and the ability to block substrate access, suggesting it could be developed into an effective anti-leishmanial drug.
Genetic engineering, including genome editing, for enhancing broad-spectrum disease resistance in crops.
Plant Commun
November 2024
National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Hubei Key Laboratory of Plant Pathology, The Center of Crop Nanobiotechnology, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:
Article Synopsis
- Plant diseases threaten global food security by reducing crop yield and quality, making the development of broad-spectrum resistance (BSR) a priority for crop protection.
- Advances in cloning disease-resistance (R) genes and understanding their molecular mechanisms are crucial for creating new genetic strategies in crop breeding.
- The review discusses recent progress in plant immunity and diverse strategies to achieve BSR, including gene stacking, genome editing techniques, and RNA interference, all aimed at improving disease-resistant crops.
A step-by-step procedure for analysing the 16S rRNA-based microbiome diversity using QIIME 2 and comprehensive PICRUSt2 illustration for functional prediction.
Arch Microbiol
November 2024
Department of Environmental Microbiology, School of Earth and Environmental Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, 226025, India.
Short-read sequencing technology has emerged as a preferred tool to analyse the bacterial composition of a niche by targeting hypervariable regions of the 16S rRNA gene. It targets the short hypervariable regions of the 16S rRNA gene and uncovers the taxonomic profile and their associated pathways. QIIME 2 is preferred and ready-to-use pipelines that perform stepwise analysis of massive short reads of 16S rRNA genes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!