In utero exposure to dichlorodiphenyldichloroethene and polychlorinated biphenyls, within the range found in the general U.S. population, may produce detectable effects in offspring. To design studies of the effects of in utero organochlorine exposure, we obtained data on the relationship between gestational and perinatal maternal levels in females on several occasions. We studied 67 pregnant women in the United States who agreed to have their blood drawn once during each trimester and once postpartum. We examined the Pearson correlation coefficient between the natural logarithm of levels (microg/g serum lipid). The correlation, r, among levels in the first and third trimester was .86 and .77 for dichlorodiphenyldichloroethene and for polychlorinated biphenyls. Correlations among levels determined at other times (i.e., second trimester and postpartum) were similar. On the basis of these results, we suggest that in studies of the effects of in utero or perinatal exposure to the aforementioned compounds, the time when specimens are collected is not critical.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/00039899909602244 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Environmental chemical burden in metabolic tissues and systemic biological pathways in adolescent bariatric surgery patients: A pilot untargeted metabolomic approach.
Environ Int
October 2020
Department of Preventive Medicine, University of Southern California, Los Angeles, CA, United States.
Article Synopsis
- Advances in untargeted metabolomic technologies can reveal how exposure to environmental chemicals affects metabolism, yet challenges include understanding the relationship between chemical exposure and biological response in different tissues.
- A pilot study analyzed the presence of persistent organic pollutants (POPs) in the adipose and liver tissues of 11 adolescents with severe obesity using ultra-high-resolution mass spectrometry.
- Results indicated that most POPs were found mainly in adipose tissue, particularly subcutaneous fat, and this accumulation correlated with significant metabolic alterations across various metabolic pathways.
Preliminary assessment of exposure to persistent organic pollutants among pregnant women in Puerto Rico.
Int J Hyg Environ Health
March 2019
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Background: Puerto Rico has over 200 hazardous waste sites, as well as higher rates of several adverse health outcomes compared to the mainland US. In response to concerns of potential links between environmental contaminant exposure and preterm birth, the Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) birth cohort was formed. Biomarkers of exposure for several contaminants have been found to be elevated in this cohort compared to women of child-bearing age in the National Health and Nutrition Examination Survey (NHANES).
View Article and Find Full Text PDFPolyhalogenated compounds (chlorinated paraffins, novel and classic flame retardants, POPs) in dishcloths after their regular use in households.
Sci Total Environ
October 2017
University of Hohenheim, Institute of Food Chemistry (170b), Garbenstr. 28, D-70599 Stuttgart, Germany. Electronic address:
Dishcloths are routinely used in the clean-up process following daily kitchen activities and are thus subject to contamination commensurate with their frequent use. Here we analyzed dishcloths for the occurrence of polyhalogenated compounds after 14days of use in household kitchens. Analysis of 19 dishcloths revealed the presence of 29 polyhalogenated contaminants with total mean/median concentrations of 6,900/3,600ng/dishcloth, respectively.
View Article and Find Full Text PDFPersistent organic pollutants in early pregnancy and risk of gestational diabetes mellitus.
Environ Int
January 2017
Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.
Background: Persistent organic pollutants (POPs) are a group of diverse substances, including polychlorinated biphenyls (PCBs) and organochlorine pesticides that are resistant to biodegradation and ubiquitously present in our environment. Exposure to endocrine disrupting chemicals such as POPs has been linked to type 2 diabetes and metabolic disturbances in epidemiological and animal studies, but little is known about POPs exposure during pregnancy and the development of gestational diabetes mellitus (GDM). The purpose of this study was to determine the extent to which exposure to current low levels of different POPs in the first trimester of pregnancy is associated with GDM risk in 939 women from the "Rhea" pregnancy cohort in Crete, Greece.
View Article and Find Full Text PDFDetermination of polychlorinated biphenyls and organochlorine pesticides in small volumes of human blood by high-throughput on-line SPE-LVI-GC-HRMS.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2014
Department of Hygiene, Social and Environmental Medicine, Ruhr-University Bochum, Universitätsstraße 150, D-44801 Bochum, Germany.
A fully automated and robust method featuring on-line solid-phase extraction (SPE) and large volume injection (LVI) gas chromatographic (GC) high resolution mass spectrometry (HRMS) is used to determine polychlorinated biphenyls (PCBs) and organochlorine pesticides, such as penta- and hexachlorobenzene (PeCBz, HxCBz), hexachlorocyclohexane isomers (HCH) and 4,4'-dichlorodiphenyldichloroethene (a metabolite of dichlorodiphenyltrichloroethane (DDT)), with only 200μl of human blood, serum or plasma. After spiking the sample with (13)C-labeled internal standards and precipitating the proteins, the sample is passed through a 10mm×2.0mm ID SPE cartridge filled with C18 material that adsorbs the analytes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!