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Acute perchloroethylene intoxication in an elderly woman: a case report.
J Med Case Rep
October 2022
School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Background: Perchloroethylene is a colorless, strong-smelling substance commonly used for dry cleaning. Liver and kidney toxicities and carcinogenicity are well-known occupational hazards caused by chronic perchloroethylene exposure. Acute intoxication by ingestion of nondiluted perchloroethylene is rare in the adult population owing to its strong smell and taste.
View Article and Find Full Text PDFAliphatic Halogenated Hydrocarbons: Report and Analysis of Liver Injury in 60 Patients.
J Clin Transl Hepatol
December 2018
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Hanau, Academic Teaching Hospital of the Medical Faculty, Goethe University Frankfurt/Main, Frankfurt/Main, Germany.
Intoxications by aliphatic halogenated hydrocarbons (AHH), used as effective solvents, are rare and may cause life-threatening liver injury. Patients with acute intoxications by AHH received an innovative treatment. Analyzed were data of 60 patients intoxicated by AHH, such as dichloromethane ( = 3), chloroform ( = 2), carbon tetrachloride ( = 12), 1,2-dichloroethane ( = 18), 1,1,2-trichloroethane ( = 2), trichloroethylene ( = 2), tetrachloroethylene ( = 13) or mixed AHH chemicals ( = 8), who received a new treatment consisting of CO-induced hyperventilation to accelerate toxin removal via the lungs.
View Article and Find Full Text PDFDeath due to acute tetrachloroethylene intoxication in a chronic abuser.
Int J Legal Med
May 2015
Sezione di Medicina Legale e delle Assicurazioni, Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Via Luigi Mangiagalli 37, Milano, Italy,
Volatile substances are used widespread, especially among young people, as a cheap and easily accessible drug. Tetrachloroethylene is one of the solvents exerting effects on the central nervous system with experiences of disinhibition and euphoria. The case presented is that of a 27-year-old female, found dead by her father at home with cotton swabs dipped in the nostrils.
View Article and Find Full Text PDFIn vitro studies show that the abused inhalant toluene affects a number of ligand-gated ion channels.The two most consistently implicated of these are γ-aminobutyric acid type A(GABAA) receptors which are positively modulated by toluene and N-methyl-D-aspartate(NMDA) receptors which are negatively modulated by toluene. Behavioral studies also suggest an interaction of toluene with GABAA and/or NMDA receptors but it is unclear if these receptors underlie the abuse-related intoxicating effects of toluene.
View Article and Find Full Text PDFThe increases in mRNA expressions of inflammatory cytokines by adding cleaning solvent or tetrachloroethylene in the murine macrophage cell line J774.1 evaluated by real-time PCR.
Ind Health
May 2014
Department of Preventive Medicine, Kitasato University School of Medicine, Japan.
The use of a petroleum-derived cleaning solvent for dry cleaning, instead of tetrachloroethylene (perchloroethylene, PCE), has increased. The cleaning solvent may induce immunological alteration. In this study, murine macrophage-lineage J774.
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