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Morphology and Immunoexpression of Selenoproteins in Term Placenta of Alpaca () from the Peruvian Andes.
Biology (Basel)
January 2025
Department of Animal Anatomy, University of Marilia, Marília 17525-902, São Paulo, Brazil.
South American camelids inhabit high-altitude environments characterized by hypoxia, influencing embryonic, fetal, and placental development. This study examined the term placenta morphology of alpacas (, N = 12) and the immunoexpression of antioxidant selenoproteins (SP). We hypothesize that the placenta of alpacas, adapted to high altitudes, has characteristics with other species also adapted to altitude.
View Article and Find Full Text PDFAssociations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium.
Clin Epigenetics
January 2025
Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Background: Night shift work during pregnancy has been associated with differential DNA methylation in placental tissue, but no studies have explored this association in cord blood. We aimed to examine associations of maternal night shift work with cord blood DNA methylation.
Methods: A total of 4487 mother-newborn pairs from 7 studies were included.
Is there an association between lateral uterine localization of the placenta and pregnancy outcomes?
Arch Gynecol Obstet
January 2025
Department of Obstetrics and Gynecology, Meir Medical Center, 59 Tchernichovsky St., 44281, Kfar Saba, Israel.
Purpose: To evaluate the association between lateral placentation and adverse perinatal outcomes, including rates of small for gestational age (SGA) neonates, hypertensive (HTN) disorders, and preterm delivery, as well as postpartum hemorrhage and retained placenta.
Methods: This retrospective cohort study included all women with singleton pregnancies who underwent a trial of labor after reaching 24 weeks of gestation, at a single tertiary medical center, over a period of 6 years. The study group included women with lateral placentation.
Effect of gestational age and fetal sex on metabolism of creatine by uteri, placentae, and fetuses of pigs†.
Biol Reprod
January 2025
Department of Animal Science, Texas A&M University, College Station, TX, USA.
The creatine (Cr) biosynthesis pathway buffers ATP in metabolically active tissues. We investigated whether sex of fetus and day of gestation influence Cr in endometrial and conceptus tissues from gilts on Days 60 and Day 90 (n = 6 gilts/day) of gestation. Uterine and conceptus tissues associated with one male and one female fetus from each gilt were analyzed for creatine, mRNAs, and proteins for Cr biosynthesis.
View Article and Find Full Text PDFThe impact of obesity on mitochondrial dysfunction during pregnancy.
Mol Cell Endocrinol
January 2025
Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil.
Mitochondria play a central role in nutrient metabolism, besides being responsible for the production of adenosine triphosphate (ATP), the main source of cellular energy. However, the ATP production process is associated with the generation of reactive oxygen species (ROS), which excessive accumulation can cause mitochondrial dysfunction. This dysfunction, in turn, causes the accumulation of fatty acids in the adipose tissue, triggering a local inflammatory process that can evolve into systemic inflammation.
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