Pol J Pharmacol
Department of Clinical Pharmacology, Jagiellonian University Medical College, Kraków, Poland.
Published: June 1999
Fourteen patients with hypercholesterolaemia were treated with bezafibrate (600 mg/day) for a month. Before and after the treatment some biochemical and physical parameters were investigated. Plasma cholesterol levels, elevated before treatment, significantly decreased after one month (p<0.001). Deformability of red blood cells increased significantly in this time (p<0.05). Total antioxidant status of serum decreased statistically significantly (p<0.01). It is concluded that the mechanism of action of bezafibrate is not connected with resistance to oxygen free radicals since the drug has no antioxidant activity. A main mechanism of action of bezafibrate seems to be lowering the cholesterol level. An increase in deformability of red blood cells may make some contribution to this mechanism.
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