1Alpha,24(R)Dihydroxy-25-nitrovitamin D3 1 and 1alpha,24(S)-dihydroxy-25-nitrovitamin D3 2 were synthesized using the palladium-catalyzed alkylative enyne cyclization reaction. Their biological properties were studied based on VDR binding affinity and HL-60 cell differentiation activity.
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| http://dx.doi.org/10.1016/s0960-894x(99)00013-x | DOI Listing |
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