AI Article Synopsis
- The study examined how sub-lethal doses of coronaviruses affect disease progression in CBA mice infected with a mild form of Trypanosoma cruzi.
- Mice were tested with different combinations of T. cruzi and coronaviruses (MHV-3 or virus X), leading to various health outcomes.
- Results showed that mice infected only with T. cruzi survived with minor health issues, while those infected with both pathogens experienced higher mortality rates and severe health complications.
- This suggests that COVID-like infections can significantly worsen the effects of T. cruzi.
Article Abstract
The effect of sub-lethal doses of coronaviruses on the course of disease in CBA mice experimentally infected with a mildly pathogenic strain of Trypanosoma cruzi was investigated. Mice were inoculated with either T. cruzi, 0.1 median lethal dose (LD50) of coronavirus (mouse hepatitis virus [MHV-3] or virus X), or both pathogens. Levels of parasitemia, mortality, and the extent of pathologic alterations in lymphoid organs were determined. Mice inoculated with T. cruzi had mild alterations in their lymphoid organs and survived infection. In contrast, mice inoculated with both pathogens died, and had significantly higher levels of parasitemia and profound alterations in lymphoid organs. These results indicate that the pathologic profile of T. cruzi infection can be profoundly altered by subclinical infection with coronaviruses.
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