A decision to withhold or withdraw life-sustaining treatment can only be justified if one (or more) of three arguments apply: (a) the patient refuses the treatment concerned, (b) the therapy cannot produce the intended medical effect, or (c) the therapy may be effective, but the effects are not meaningful. Assessment of effectiveness is a medical professional judgement. This assessment should take into account the proportionality of medical (technological) means and ends. Treatment is meaningful if (a) it serves a reasonable purpose for the patient, and (b) the benefits outweigh the burdens for the patient. The patient's own view determines the meaningfulness of treatment. Physicians should talk with patients about the meaningfulness of life-sustaining treatment while there is time, to avoid the situation that such questions come up just when a patient has lost his capacity to communicate. In case a patient is incompetent, physicians should try to infer from previous utterances of the patient what he or she would have wished in this situation. If it is impossible to reconstruct the patient's view, there is no basis for withdrawing or withholding medically effective life-sustaining treatment.
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Pediatr Blood Cancer
January 2025
Department of Oncology and Hospitalist Medicine Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Purpose: To assess the level of moral distress (MD) and perceptions of ethical climate among pediatric hematology/oncology (PHO) nurses and to identify bioethics topics where increased education was desired.
Methods: In this cross-sectional study, we administered the 26-item Swedish Moral Distress Scale-Revised (sMDS-R), specifically revised and validated for pediatric oncology, in conjunction with the Clinical Ethics Needs Assessment Survey (CENAS). Electronic surveys were sent to inpatient and outpatient PHO nurses.
Kidney Med
November 2024
Division of Geriatrics and Extended Care, Edward Hines, Jr. VA Hospital, Hines, IL.
Rationale & Objective: Engaging patients with advanced chronic kidney disease (CKD) in goals of care (GOC) conversations is essential to align life-sustaining treatments with patient preferences. This pilot study described the feasibility of engaging older Veterans with advanced CKD in GOC conversations via telehealth by (1) comparing patient characteristics, including life-sustaining treatment note completion rates and preferences by visit modality, and (2) exploring Veteran and clinician perspectives surrounding telehealth GOC conversations.
Study Design: Mixed-method convergent design including a prospective, quantitative observational cohort analysis (n = 40) and qualitative, semi-structured interviews with 4 clinicians and 11 Veterans.
JAMA Netw Open
January 2025
Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.
Importance: Eligibility criteria for randomized clinical trials (RCTs) are designed to select clinically relevant patient populations. However, not all eligibility criteria are strongly justified, potentially excluding marginalized groups, and limiting the generalizability of trial findings.
Objective: To summarize and evaluate the justification of exclusion criteria in published RCTs in critical care medicine.
Ann Intensive Care
January 2025
Medical Intensive Care Unit, Saint-Louis Teaching Hospital, Paris University, 1 Avenue Claude Vellefaux, Paris, 75010, France.
Background: To describe the use of life-sustaining therapies and mortality in patients with acute leukemia admitted to the intensive care unit (ICU).
Methods: The PubMed database was searched from January 1st, 2000 to July 1st, 2023. All studies including adult critically ill patients with acute leukemia were included.
Camb Q Healthc Ethics
January 2025
Nova Southeastern University Shepard Broad College of Law, Fort Lauderdale, FL, USA.
Conscious but incapacitated patients need protection from both undertreatment and overtreatment, for they are exceptionally vulnerable, and dependent on others to act in their interests. In the United States, the law prioritizes autonomy over best interests in decision making. Yet U.
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