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Data collected from scholars across twenty-three countries over the past decade (2010-2019) reveals a 40% decrease in financial support for medicinal chemistry projects. The decline is especially notable among projects focused on small organic molecules. This drop in grants indicates a troubling trend that could jeopardize future drug development by undermining research in this crucial field.

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Effects of Hydration and a Hyaluronic Acid-Containing Lozenge on Voice Parameters in Conjunction With a Vocal Loading Test.

J Speech Lang Hear Res

January 2025

Division of Phoniatrics and Pediatric Audiology, Department of Otolaryngology, Munich University Hospital and Faculty of Medicine, Munich University (Ludwig-Maximilians-Universität), Germany.

Purpose: This study explores the effects of water intake and a hyaluronic acid (HA)-containing lozenge on acoustic measurements and vocal oscillation patterns investigated after a vocal loading test (VLT).

Method: Ten healthy subjects (five females, five males) read out loud a standardized text for 10 min at a target level of 80 dB(A), measured 30 cm from the mouth, under three conditions but each after fasting for 2 hr: (a) drinking 0.7 l of water, (b) sucking an HA-containing lozenge, and (c) neither of both before the VLT.

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Background And Aims: It is assumed that trees should adapt their above and belowground organs as they age. However, most studies to date have quantified these trait adjustments in homogeneous forest stands, confounding the effect of stand aging on soil properties and the intrinsic response of trees to aging.

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Ubiquitin-conjugating enzymes (E2s) are key for protein turnover and quality control via ubiquitination. Some E2s also physically interact with the proteasome, but it remains undetermined which E2s maintain proteostasis during aging. Here, we find that E2s have diverse roles in handling a model aggregation-prone protein (huntingtin-polyQ) in the Drosophila retina: while some E2s mediate aggregate assembly, UBE2D/effete (eff) and other E2s are required for huntingtin-polyQ degradation.

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