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AP39, a novel mitochondria-targeted hydrogen sulfide donor, promotes cutaneous wound healing in an in vivo murine model of acute frostbite injury.
Biomed Pharmacother
January 2025
Department of Surgery, Division of Urology, London Health Sciences Center, Western University, London, Ontario, Canada; Matthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, Ontario, Canada; Multi-Organ Transplant Program, London Health Sciences Center, Western University, London, Ontario, Canada; Department of Microbiology & Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada. Electronic address:
Frostbite injury refers to cold tissue injury which typically affects the peripheral areas of the body, and is associated with limb loss and high rates of morbidity. Historically, treatment options have been limited to supportive care, leading to suboptimal outcomes for affected patients. The pathophysiology of frostbite injury has been understood in recent years to share similarity with that of cold ischemia-reperfusion injury as seen in solid organ transplantation, of which mitochondria play an important contributing role.
View Article and Find Full Text PDFA call to action for disrupting microaggressions, improving interprofessional collaboration, and optimizing outcomes: Nurse leaders have a role.
Nurs Outlook
January 2025
School of Nursing, University of Pennsylvania, Philadelphia, PA.
Background: Microaggressions are pervasive in clinical and academic environments, often unnoticed by those unaware of the privileges and power dynamics tied to socially constructed hierarchies. These subtle manifestations of bias and prejudice are typically directed toward historically marginalized individuals and groups (HMIGs), contributing to a toxic culture that undermines interprofessional communication, collaboration, and healthcare delivery.
Purpose: This article aims to explore the concept of microaggressions and their impact on healthcare environments.
The shifting of buffer crop repertoires in pre-industrial north-eastern Europe.
Sci Rep
January 2025
Department of Archaeology, Faculty of History, Vilnius University, Universiteto St. 7, Vilnius, 01513, Lithuania.
This study explores how major climatic shifts, together with socioeconomic factors over the past two millennia, influenced buffer crop selection, focusing on five crops: rye, millet, buckwheat, oat, and hemp. For this study, we analyzed archaeobotanical data from 135 archaeological contexts and historical data from 242 manor inventories across the northeastern Baltic region, spanning the period from 100 to 1800 AD. Our findings revealed that rye remained a main staple crop throughout the studied periods reflecting environmental adaptation to northern latitudes.
View Article and Find Full Text PDFInvestigate physiological and psychological responses to environment scenes, elements and components in different urban settings.
Sci Rep
January 2025
Institute of Geography, School of GeoSciences, University of Edinburgh, Edinburgh, UK.
Research has proved a close relationship between environments and physiological as well as psychological responses. However, existing research based on neuroscience experiments demonstrated a clear dichotomy between natural and built environments in the selection of exposure settings. There is very limited research analyzing and comparing the effects of different urban environments on individual psychological health.
View Article and Find Full Text PDFJuhn Atushi Wada (1924-2023) and the history of the Wada test.
J Clin Neurosci
January 2025
Department of Neurology, Northwell Health, New Hyde Park, NY, USA. Electronic address:
Epilepsy is one of the most common neurologic conditions in the world. Surgical treatment for refractoryepilepsy is a method to optimize the quality of life for patients. Throughout his medical career, Dr.
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