In this paper we are summarizing our observations collected during several years and concerning the inflammatory changes in maturing human brains. Studies of inflammatory reactions in developing central nervous system (CNS) revealed that their morphological picture changes along with the maturation of the brain and formation of fetal immune response. We have analyzed various types of inflammatory processes (meningeal infiltrations, meningoencephalitis with perivascular infiltrates and glial interstitial changes, inflammatory-necrotic lesions) occurring in different stages of brain development. In all these processes gradual maturation of cell lines belonging to the immune system was seen. Evident correlation between tissue inflammatory reaction and necrosis was confirmed. The necrotic changes mainly within hemispheric white matter may result in the cortical malformations. The morphologic manifestation of inflammation in the developing CNS is dependent on the stage of maturation of the brain structure and immunological response.
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