Purpose: This report presents the final stage of our program to improve the quality of our superficial hyperthermia treatments. We have already demonstrated that the Lucite cone applicator (LCA), our technically improved water-filled, wave-guide applicator (WGA), is superior to the conventional WGA. The main objective of the present study was to investigate whether the technical improvements of a WGA were reflected in an improved clinical performance, e.g., a better temperature distribution.
Methods And Materials: Power and temperature analyses were performed retrospectively on 128 treatments of superficially located tumors (less than 4 cm depth). Twenty-three patients were treated alternately with a WGA setup and a LCA setup.
Results: The average power level per antenna in an array was 48 W and 62 W for the WGA and LCA respectively. The average invasively measured temperatures increased by 0.27 degrees C when the LCAs were used. The temperature difference between the center and the periphery of an antenna, averaged over the complete array of antennae, was 0.43 degrees C using WGAs and -0.05 degrees C using LCAs indicating a more uniform heating. The T90 of the invasively measured temperatures remained unchanged (WGA: 39.4 degrees C versus LCA: 39.5 degrees C).
Conclusion: The LCA is now our standard applicator for superficial hyperthermia treatments as it is technically and clinically proven to be superior to the WGA.
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http://dx.doi.org/10.1016/s0360-3016(98)00443-x | DOI Listing |
Int J Hyperthermia
November 2024
ElmediX NV, Leuven, Belgium.
Objectives: This study aims to design and fabricate a modular phantom for hyperthermia applications, addressing interpatient variability in thermal regulation mechanisms like sweating rate, metabolic heat production, and blood redistribution.
Materials & Methods: The phantom can be constructed in various weights and dimensions by connecting identical units. Each unit consists of an agar-based block, an ethyl cellulose-based top layer, a heat source, deep and superficial water circulation, and a sweating mechanism.
Am J Dermatopathol
August 2024
Pathology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Biomed Phys Eng Express
May 2024
Department of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University-Harrisburg, Middletown, PA 17057, United States of America.
Magnetic nanoparticle hyperthermia (MNPH) has emerged as a promising cancer treatment that complements conventional ionizing radiation and chemotherapy. MNPH involves injecting iron-oxide nanoparticles into the tumor and exposing it to an alternating magnetic field (AMF). Iron oxide nanoparticles produce heat when exposed to radiofrequency AMF due to hysteresis loss.
View Article and Find Full Text PDFInt J Hyperthermia
April 2024
Department of Radiation Oncology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Purpose: To analyze the current practice of regional hyperthermia (RHT) for soft tissue sarcoma (STS) at 12 European centers to provide an overview, find consensuses and identify controversies necessary for future guidelines and clinical trials.
Methods: In this cross-sectional survey study, a 27-item questionnaire assessing clinical subjects and procedural details on RHT for STS was distributed to 12 European cancer centers for RHT.
Results: We have identified seven controversies and five consensus points.
J Therm Biol
April 2024
Department of Morphology, Federal University of Pelotas, Av. Eliseu Maciel, Capão do Leão, RS, Brazil. Electronic address:
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