[Delayed-type hypersensitivity in insulin-dependent diabetes mellitus and effects of short-action insulins produced by different pharmaceutical firms].

Aim: The study of activity of T-effector lymphocytes of delayed-type hypersensitivity (DTH) in insulin-dependent diabetes (IDD) and effects of short-action insulins produced by different pharmaceutical firms.

Materials And Methods: 79 IDD patients aged 3-48 entered the study.

Results: T-effector lymphocytes activity in DTH patients was abnormal: leukocytes migration was enhanced due to inhibited production of the inhibiting factor. Effector function was subnormal. Short-acting insulins promoted normalization of the above indices. The insulins of different producers is individual in efficacy for each patient.

Conclusion: In vitro tests are necessary for each patient to determine insulin activity before insulin therapy.